Grb2 associated binding protein 3
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External IDs | GeneCards: [1] | ||||||
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Species | Human | Mouse | |||||
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Location (UCSC) | n/a | n/a | |||||
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GRB2 associated binding protein 3 is a protein that in humans is encoded by the GAB3 gene. [1]
Function
This gene is a member of the GRB2-associated binding protein gene family. These proteins are scaffolding/docking proteins that are involved in several growth factor and cytokine signaling pathways, and they contain a pleckstrin homology domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. The protein encoded by this gene facilitates macrophage differentiation. Alternative splicing results in multiple transcript variants.
References
- ↑ "Entrez Gene: GRB2 associated binding protein 3". Retrieved 2016-07-26.
Further reading
- Bourgin C, Bourette RP, Arnaud S, Liu Y, Rohrschneider LR, Mouchiroud G (2002). "Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation". Mol. Cell. Biol. 22 (11): 3744–56. doi:10.1128/mcb.22.11.3744-3756.2002. PMC 133813. PMID 11997510.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.