Non-alcoholic fatty liver disease causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]

Overview

There are no clear causes of NAFLD, although various disorders are strongly associated with it including obesity, diabetes mellitus type 2, and dyslipidemia, all of which are components of the metabolic syndrome. Other less common causes of non-alcoholic fatty liver disease include oxidative stress, hormonal imbalances, endotoxemia and mitochondrial abnormalities.

Causes

• The most common cause of NAFLD are conditions associated with obesity such as insulin resistance and metabolic syndrome. It is estimated that approximately 80% of the obese people suffer from NAFLD.

• Less common causes of non-alcoholic fatty liver disease include hypertension and dyslipidemia.

Secondary NAFLD

Secondary non-alcoholic fatty liver disease can also be defined as injury to liver caused by either medications, surgery and other diseases.

• Amiodarone
• Antiviral drugs (nucleoside analogues)
• Aspirin / NSAIDS
• Corticosteroids
• Methotrexate
• Nifedipine
• Perhexiline
• Tamoxifen
• Tetracycline
• Valproic acid

References

Non-Alcoholic Fatty Liver Disease Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Non-Alcoholic Fatty Liver Disease from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
X Ray
CT
MRI
Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case studies
Case #1
Non-alcoholic fatty liver disease causes On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Non-alcoholic fatty liver disease causes All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Non-alcoholic fatty liver disease causes
CDC on Non-alcoholic fatty liver disease causes
Non-alcoholic fatty liver disease causes in the news
Blogs on Non-alcoholic fatty liver disease causes
Directions to Hospitals Treating Non-alcoholic fatty liver disease
Risk calculators and risk factors for Non-alcoholic fatty liver disease causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [3]; Associate Editor(s)-in-Chief:

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