Alcoholic liver disease historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: M. Khurram Afzal, MD [2]

Historical Perspective

• Alcohol has existed as the most abused substance for many centuries
• In 1960 alcohol was recognized as a hepatotoxin
• The earliest lesion reported for alcoholic liver disease is alcoholic steatosis (fatty liver)