Alpha 1-antitrypsin deficiency CT
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
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Overview
On High-resolution CT (HRCT) scan of the chest: hypoattenuated areas resulting from a lack of lung tissue. As tissue is lost, pulmonary vessels appear smaller, fewer in number, and spread farther apart. Mild forms of alpha1-antitrypsin disease can be missed on HRCT scanning. However, when the disease is moderate, discerning the panlobular and characteristic lower zone predominance is possible. Severe forms may be indistinguishable from severe centrilobular emphysema. normal lung structures have been replaced by abnormal airspaces CT of abdomen may show hepatomegaly or changes associated with cirrhosis or hepatocellular carcinoma.
CT
On High-resolution CT (HRCT) scan of the chest:[1]
- Hypoattenuated areas resulting from a lack of lung tissue. As tissue is lost, pulmonary vessels appear smaller, fewer in number, and spread farther apart. Mild forms of alpha1-antitrypsin disease can be missed on HRCT scanning.
- However, when the disease is moderate, discerning the panlobular and characteristic lower zone predominance is possible.
- Severe forms may be indistinguishable from severe centrilobular emphysema. Normal lung structures have been replaced by abnormal airspaces
- CT of abdomen may show hepatomegaly or changes associated with cirrhosis or hepatocellular carcinoma.
