Linitis plastica other diagnostic studies
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Hadeel Maksoud M.D.[2]
Overview
Brush cytology may be helpful in the diagnosis of linitis plastica. Brush cytology has the ability to increase the sensitivity of even a single biopsy carried out by endoscopic ultrasound. If bleeding is a concern in the patient, brush cytology is able to take samples of the mucosa without bleeding. Immunohistochemical staining then confirms the diagnosis of linitis plastica with the finding of signet ring cells. Genetic testing can be carried out in those who have family history of hereditary diffuse gastric adenocarcinoma and are postive for CDH1 mutation. The risk for developing gastric cancer is high enough to warrant prophylactic gastrectomy.
Other Diagnostic Studies
Brush cytology
- Brush cytology with immunohistochemical staining may be helpful in the diagnosis of linitis plastica.[1]
- Brush cytology has the following advantages:
- No risk of bleeding
- Increased sensitivity of single biopsy
- Sensitive to poorly differentiated linits plastica