Gallbladder cancer pathophysiology

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Overview

It is thought that gallbladder cancer is the result of chronic irritation of the gallbladder mucosa over a duration of years may predispose to malignant transformation.

Pathophysiology

Pathogenesis

  • It is understood that gallbladder cancer is the result of chronic irritation or inflmation of the gallbladder
  • In most of patients (>75%), the nidus of this chronic inflammation is  gallstones. 
  • Gallbladder cancer affects most commonly females 2-3 times than males[1]
  • The hormone estrogen in females causes super saturation in bile and increases the risk of gallstone mediated GBC pathogenesis
  1. ↑ Lazcano-Ponce EC, Miquel JF, Muñoz N, Herrero R, Ferrecio C, Wistuba II, Alonso de Ruiz P, Aristi Urista G, Nervi F (2001). "Epidemiology and molecular pathology of gallbladder cancer". CA Cancer J Clin. 51 (6): 349–64. PMID 11760569.
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