Hepatocellular carcinoma causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Dildar Hussain, MBBS [2] Mohamad Alkateb, MBBCh [3]
Overview
Common causes of hepatocellular carcinoma include hepatitis B, hepatitis C, alcoholic liver cirrhosis, hemochromatosis, and hepatic porphyrias.
Common Causes
Common causes of hepatocellular carcinoma include the following:[1][2][3]
- Hepatitis B
- Hepatitis C
- Liver cirrhosis
- Aflatoxins
- Hemochromatosis
- Hepatic porphyrias (acute intermittent porphyria, porphyria cutanea tarda, hereditary coproporphyria, and variegate porphyria)
- Tyrosinemia type 1
Less common causes
Common causes of hepatocellular carcinoma include the following:[4]
- Non alcholic fatty liver disease(NAFLD)
- Non alchoholic steatohepatitis(NASH)
- Metabolic disorders
- Diabetes mellitus type II
- Obesity
- Metabolic syndrome
- Gut microbiota[5]
- Drugs:
References
- ↑ Jiang, Kun; Centeno, Barbara A. (2018). "Primary Liver Cancers, Part 2". Cancer Control. 25 (1): 107327481774465. doi:10.1177/1073274817744658. ISSN 1073-2748.
- ↑ Said, Adnan; Ghufran, Aiman (2017). "Epidemic of non-alcoholic fatty liver disease and hepatocellular carcinoma". World Journal of Clinical Oncology. 8 (6): 429–436. doi:10.5306/wjco.v8.i6.429. ISSN 2218-4333.
- ↑ Erkekoglu P, Oral D, Chao MW, Kocer-Gumusel B (2017). "Hepatocellular Carcinoma and Possible Chemical and Biological Causes: A Review". J. Environ. Pathol. Toxicol. Oncol. 36 (2): 171–190. doi:10.1615/JEnvironPatholToxicolOncol.2017020927. PMID 29199597.
- ↑ Agosti, Pasquale; Sabbà, Carlo; Mazzocca, Antonio (2018). "Emerging metabolic risk factors in hepatocellular carcinoma and their influence on the liver microenvironment". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1864 (2): 607–617. doi:10.1016/j.bbadis.2017.11.026. ISSN 0925-4439.
- ↑ Sanduzzi Zamparelli M, Rocco A, Compare D, Nardone G (2017). "The gut microbiota: A new potential driving force in liver cirrhosis and hepatocellular carcinoma". United European Gastroenterol J. 5 (7): 944–953. doi:10.1177/2050640617705576. PMC 5676553. PMID 29163959.