Sjögren's syndrome pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Farbod Zahedi Tajrishi, M.D.
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Overview
ُSjögren's syndrome is a chronic auto-immune disorder that can affect several organ systems. Both genetic and immune factors contribute to the pathogenesis of the disease. Lymphocytes (primarily CD4+ T-cells) infiltrate the lacrimal and salivary glands and impair their function, hence causing the main characteristic symptoms of the disease- dry mouth (keratoconjunctivitis sicca) and eyes (xerostomia).
Pathophysiology
The pathogenesis of Sjögren's syndrome can be linked to both genetic and nongenetic components [1].
- Genetic components:
Evidence suggests genes that encode Major Histocompatibility Complex (MHC), particularly HLA genes, play an important role in the disease.
References
- ↑ Mavragani CP, Nezos A, Moutsopoulos HM (2013). "New advances in the classification, pathogenesis and treatment of Sjogren's syndrome". Curr Opin Rheumatol. 25 (5): 623–9. doi:10.1097/BOR.0b013e328363eaa5. PMID 23846338.