Chronic cholecystitis risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aditya Govindavarjhulla, M.B.B.S. [2]

Overview

Common risk factors in the development of calculous cholecystitis (cholelithiasis) include female gender, increasing age, obesity, pregnancy, hormonal therapy in women, and sickle cell disease. Common risk factors in the development of acalculous cholecystitis include AIDS, diabetes mellitus, major surgery, burns, sepsis, and long term total parenteral nutrition use.

Risk Factors

  • Common risk factors in the development of acute calculous cholecystitis include advancing age, female gender, obesity, and family history. Long periods of fasting, total parental nutrition (TPN), weight loss are the common risk factors for the development of acute acalculous cholecystitis.

Common Risk Factors

Less Common Risk Factors

  • Less common risk factors in the development of acute cholecystitis include:[5]
  • Bacterial/ protozoal infections

Acalculous Cholecystitis

Calculous Cholecystitis (Cholelithiasis)

  • Female gender
  • Hormonal therapy in women
  • Increasing age
  • Obesity
  • Pregnancy
  • Race: Scandinavians > African-Americans
  • Rapid weight loss
  • Sickle Cell Disease

References

  1. Knab LM, Boller AM, Mahvi DM (2014). "Cholecystitis". Surg. Clin. North Am. 94 (2): 455–70. doi:10.1016/j.suc.2014.01.005. PMID 24679431.
  2. Ruhl CE, Everhart JE (2000). "Association of diabetes, serum insulin, and C-peptide with gallbladder disease". Hepatology. 31 (2): 299–303. doi:10.1002/hep.510310206. PMID 10655249.
  3. Tsai CJ, Leitzmann MF, Willett WC, Giovannucci EL (2006). "Central adiposity, regional fat distribution, and the risk of cholecystectomy in women". Gut. 55 (5): 708–14. doi:10.1136/gut.2005.076133. PMC 1856127. PMID 16478796.
  4. Jones MW, Ferguson T. "Gallbladder, Cholecystitis, Acalculous". PMID 29083717.
  5. Kimura Y, Takada T, Kawarada Y, Nimura Y, Hirata K, Sekimoto M, Yoshida M, Mayumi T, Wada K, Miura F, Yasuda H, Yamashita Y, Nagino M, Hirota M, Tanaka A, Tsuyuguchi T, Strasberg SM, Gadacz TR (2007). "Definitions, pathophysiology, and epidemiology of acute cholangitis and cholecystitis: Tokyo Guidelines". J Hepatobiliary Pancreat Surg. 14 (1): 15–26. doi:10.1007/s00534-006-1152-y. PMC 2784509. PMID 17252293.


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