Gastroparesis pathophysiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Madhu Sigdel M.B.B.S.[2]

Overview

The exact pathogenesis of gastroparesis is not fully understood. However, gastric emptying process is the result of interaction of smooth muscles, extrinsic and enteric autonomic nervous system, and interstitial cells of Cajal (ICC). Loss of expression of neuronal nitric oxide synthase (nNOS) and loss of interstitial cells of Cajal (ICC) play pivotal role in the pathogenesis of gastroparesis.

Pathophysiology

Pathogenesis

Genetics

  • Recent studies suggest that the loss of antioxidant gene expression (NRF2 gene) can contribute to the development of gastroparesis. NRF2 regulates expression of Phase II antioxidant genes as HO-1, SOD1, SOD2, GCLC, GCLM, CAT, and GPX1.[8] Elevated expression of the enzyme (heme oxygenase-1) product of gene HO-1 can mitigate the development of grastroparesis.[9] High oxidative stress in interstitial cells of Cajal and nitrergic enteric nerves are the potential cause of injury and decrease in their numbers.[8]

Associated Conditions

The following conditions may be associated with gastroparesis:

Gross Pathology

On gross pathology, no abnormalities seen on obtaining full thickness biopsy of gastric tissue.

Microscopic Pathology

On microscopic histopathological analysis of full thickness biopsy of the gastric body. Decreased number of interstitial cells of Cajal (also called fibroblast like cells) in circular muscle layer, immune cells infiltration of gastric tissue especially myenteric plexus predominantly consisting of lymphocytes and macrophages showing CD45 and CD68 immunoreactivity,[3] and Circular muscles enteric nerve fibre loss are characteristic findings of gastroparesis.[11]

References

  1. 1.0 1.1 Oh JH, Pasricha PJ (2013). "Recent advances in the pathophysiology and treatment of gastroparesis". J Neurogastroenterol Motil. 19 (1): 18–24. doi:10.5056/jnm.2013.19.1.18. PMC 3548121. PMID 23350043.
  2. Camborová P, Hubka P, Sulková I, Hulín I (2003). "The pacemaker activity of interstitial cells of Cajal and gastric electrical activity". Physiol Res. 52 (3): 275–84. PMID 12790758.
  3. 3.0 3.1 Parkman HP (2015). "Idiopathic gastroparesis". Gastroenterol Clin North Am. 44 (1): 59–68. doi:10.1016/j.gtc.2014.11.015. PMC 4324534. PMID 25667023.
  4. Cheng LK (2015). "Slow wave conduction patterns in the stomach: from Waller's foundations to current challenges". Acta Physiol (Oxf). 213 (2): 384–93. doi:10.1111/apha.12406. PMC 4405773. PMID 25313679.
  5. Anuras S, Cooke AR, Christensen J (1974). "An inhibitory innervation at the gastroduodenal junction". J Clin Invest. 54 (3): 529–35. doi:10.1172/JCI107789. PMC 301585. PMID 4152775.
  6. Ekblad E, Mulder H, Uddman R, Sundler F (1994). "NOS-containing neurons in the rat gut and coeliac ganglia". Neuropharmacology. 33 (11): 1323–31. PMID 7532815.
  7. Sivarao DV, Mashimo H, Goyal RK (2008). "Pyloric sphincter dysfunction in nNOS-/- and W/Wv mutant mice: animal models of gastroparesis and duodenogastric reflux". Gastroenterology. 135 (4): 1258–66. doi:10.1053/j.gastro.2008.06.039. PMC 2745304. PMID 18640116.
  8. 8.0 8.1 Mukhopadhyay S, Sekhar KR, Hale AB, Channon KM, Farrugia G, Freeman ML; et al. (2011). "Loss of NRF2 impairs gastric nitrergic stimulation and function". Free Radic Biol Med. 51 (3): 619–25. doi:10.1016/j.freeradbiomed.2011.04.044. PMC 3129370. PMID 21605664.
  9. Gibbons SJ, Grover M, Choi KM, Wadhwa A, Zubair A, Wilson LA; et al. (2017). "Repeat polymorphisms in the Homo sapiens heme oxygenase-1 gene in diabetic and idiopathic gastroparesis". PLoS One. 12 (11): e0187772. doi:10.1371/journal.pone.0187772. PMC 5697813. PMID 29161307.
  10. Triadafilopoulos G, Nguyen L, Clarke JO (2017). "Patients with symptoms of delayed gastric emptying have a high prevalence of oesophageal dysmotility, irrespective of scintigraphic evidence of gastroparesis". BMJ Open Gastroenterol. 4 (1): e000169. doi:10.1136/bmjgast-2017-000169. PMC 5689484. PMID 29177065.
  11. Grover M, Bernard CE, Pasricha PJ, Lurken MS, Faussone-Pellegrini MS, Smyrk TC; et al. (2012). "Clinical-histological associations in gastroparesis: results from the Gastroparesis Clinical Research Consortium". Neurogastroenterol Motil. 24 (6): 531–9, e249. doi:10.1111/j.1365-2982.2012.01894.x. PMC 3353102. PMID 22339929.

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