Tabes Dorsalis natural history, complications, and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]

Overview

If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].

OR

Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].

OR

Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.

The symptoms of tabes dorsalis usually develop secondary to long-term untreated syphilis, and start with symptoms such as;

lightning pains^[1]

Impaired sensation and proprioception^[2]
Hypesthesias^[3].
The symptoms of tabes dorsalis typically occurs 10 to 30 years after primary infection by treponema pallidum.
If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].

Common complications of [disease name] include:
- [Complication 1]
- [Complication 2]
- [Complication 3]

Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.
Depending on the extent of the [tumor/disease progression/etc.] at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor/good/excellent.
The presence of [characteristic of disease] is associated with a particularly [good/poor] prognosis among patients with [disease/malignancy].
[Subtype of disease/malignancy] is associated with the most favorable prognosis.
The prognosis varies with the [characteristic] of tumor; [subtype of disease/malignancy] have the most favorable prognosis.

Complications of late-stage syphilis infection, which may include:
- Inflammation of the aorta (aortitis) with aortic aneurysm
- Disease of the heart valves
- Damage to bones, skin, and other organs
Complications of neurosyphilis, including dementia, stroke, eye disease
Difficulty with walking and balance
Paralysis

Progressive disability is possible if the disorder is left untreated.