Diaphragmatic paralysis causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mahda Alihashemi M.D. [2]

Overview

Disease name] may be caused by [cause1], [cause2], or [cause3].

OR

Common causes of [disease] include [cause1], [cause2], and [cause3].

OR

The most common cause of [disease name] is [cause 1]. Less common causes of [disease name] include [cause 2], [cause 3], and [cause 4].

OR

The cause of [disease name] has not been identified. To review risk factors for the development of [disease name], click here.

Causes

Life-threatening Causes

  • Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated. There are no life-threatening causes of disease name, however complications resulting from untreated disease name is common.
  • Life-threatening causes of [symptom/manifestation] include [cause1], [cause2], and [cause3].
  • [Cause] is a life-threatening cause of [disease].

Common Causes

Unilateral diaphragmatic paralysis :[1]

  • Idiopathic in many cases
  • Phrenic nerve injury in cardiac surgery due to cooling or streching [2]
  • Viral infections such as:
    • Herpes zoster
    • Poliomyelitis

Bilateral diaphragmatic paralysis:[3]

  • Idiopathic in many cases
  • Cervical spinal cord disease such as
    • Large tumors
    • Spinal cord transection
  • Motor neuron disease such as: [4]
    • Amyotrophic lateral sclerosis
  • Neuropathy
    • Post-polio syndrome
    • Guillain-Barré syndrome
    • Post-viral neuropathy ( West Nile virus )[5]
    • Thyroid Disease
    • Autoimmune diseases
  • Neuromuscular junction disease 
    • Myasthenia gravis[6]
    • Eaton Lambert Syndrome [7]
    • Systemic botulism 
  • Muscle disease 
    • Polymyositis
    • Dermatomyositis
    • Inclusion body myopathy
    • Limb-girdle muscular dystrophy
    • Acid maltase deficiency 
    • Hypothyroidism
    • Hyperthyroidism

Less Common Causes

Unilateral diaphragmatic paralysis : [8]

  • Cervical spondylosis
  • Cervical compressive tumors
  • Blunt neck trauma
  • Neck surgery
  • Pneumonia
  • Iatrogenic embolization such as bronchial artery embolization for treatment of hemoptysis
  • Neuralgic amyotrophy, inflammatory disorder of brachial plexus[9]

Bilateral diaphragmatic paralysis :[3]

Less common causes of diaphragmatic paralysis include:

  • Parsonage Turner syndrome (brachial neuritis or neuralgic amyotrophy)
  • Malnutrition[10]

Genetic Causes

  • Diaphragmatic paralysis due to spinal muscular atrophy caused by a mutation in the survival motor neuron 1 (SMN1) gene on chromosome 5q13.2.[11]
  • Acid maltase deficency as a cause of diaphragmatic paralysis caused by a mutation in GAA gene on chromosome band 17q23.[12]

Causes by Organ System

Cardiovascular No underlying causes
Chemical/Poisoning No underlying causes
Dental No underlying causes
Dermatologic No underlying causes
Drug Side Effect No underlying causes
Ear Nose Throat No underlying causes
Endocrine No underlying causes
Environmental No underlying causes
Gastroenterologic No underlying causes
Genetic No underlying causes
Hematologic No underlying causes
Iatrogenic No underlying causes
Infectious Disease No underlying causes
Musculoskeletal/Orthopedic No underlying causes
Neurologic No underlying causes
Nutritional/Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic No underlying causes
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal/Electrolyte No underlying causes
Rheumatology/Immunology/Allergy No underlying causes
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous No underlying causes

Causes in Alphabetical Order

List the causes of the disease in alphabetical order.

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3

References

  1. Dubé, Bruno-Pierre; Dres, Martin (2016). "Diaphragm Dysfunction: Diagnostic Approaches and Management Strategies". Journal of Clinical Medicine. 5 (12): 113. doi:10.3390/jcm5120113. ISSN 2077-0383.
  2. Canbaz S, Turgut N, Halici U, Balci K, Ege T, Duran E (2004). "Electrophysiological evaluation of phrenic nerve injury during cardiac surgery--a prospective, controlled, clinical study". BMC Surg. 4: 2. doi:10.1186/1471-2482-4-2. PMC 320489. PMID 14723798.
  3. 3.0 3.1 Dubé BP, Dres M (2016). "Diaphragm Dysfunction: Diagnostic Approaches and Management Strategies". J Clin Med. 5 (12). doi:10.3390/jcm5120113. PMC 5184786. PMID 27929389.
  4. Chen R, Grand'Maison F, Strong MJ, Ramsay DA, Bolton CF (1996). "Motor neuron disease presenting as acute respiratory failure: a clinical and pathological study". J. Neurol. Neurosurg. Psychiatry. 60 (4): 455–8. PMC 1073907. PMID 8774419.
  5. Betensley AD, Jaffery SH, Collins H, Sripathi N, Alabi F (2004). "Bilateral diaphragmatic paralysis and related respiratory complications in a patient with West Nile virus infection". Thorax. 59 (3): 268–9. PMC 1746955. PMID 14985569.
  6. Valadas A, de Carvalho M (2008). "Myasthenia gravis and respiratory failure related to phrenic nerve lesion". Muscle Nerve. 38 (4): 1340–1. doi:10.1002/mus.21067. PMID 18785183.
  7. Nicolle, Michael W.; Stewart, Dwight J.; Remtulla, Hussein; Chen, Robert; Bolton, Charles F. (1996). "Lambert-Eaton myasthenic syndrome presenting with severe respiratory failure". Muscle & Nerve. 19 (10): 1328–1333. doi:10.1002/(SICI)1097-4598(199610)19:10<1328::AID-MUS10>3.0.CO;2-Q. ISSN 0148-639X.
  8. Chapman SA, Holmes MD, Taylor DJ (2000). "Unilateral diaphragmatic paralysis following bronchial artery embolization for hemoptysis". Chest. 118 (1): 269–70. PMID 10893396.
  9. Tsao BE, Ostrovskiy DA, Wilbourn AJ, Shields RW (2006). "Phrenic neuropathy due to neuralgic amyotrophy". Neurology. 66 (10): 1582–4. doi:10.1212/01.wnl.0000216140.25497.40. PMID 16717226.
  10. Murciano, D; Rigaud, D; Pingleton, S; Armengaud, M H; Melchior, J C; Aubier, M (1994). "Diaphragmatic function in severely malnourished patients with anorexia nervosa. Effects of renutrition". American Journal of Respiratory and Critical Care Medicine. 150 (6): 1569–1574. doi:10.1164/ajrccm.150.6.7952616. ISSN 1073-449X.
  11. Sivan Y, Galvis A (1990). "Early diaphragmatic paralysis. In infants with genetic disorders". Clin Pediatr (Phila). 29 (3): 169–71. doi:10.1177/000992289002900305. PMID 2407409.
  12. Kishnani PS, Steiner RD, Bali D, Berger K, Byrne BJ, Case LE, Case L, Crowley JF, Downs S, Howell RR, Kravitz RM, Mackey J, Marsden D, Martins AM, Millington DS, Nicolino M, O'Grady G, Patterson MC, Rapoport DM, Slonim A, Spencer CT, Tifft CJ, Watson MS (2006). "Pompe disease diagnosis and management guideline". Genet. Med. 8 (5): 267–88. doi:10.109701.gim.0000218152.87434.f3 Check |doi= value (help). PMC 3110959. PMID 16702877.

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