Sandbox:Chandra
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Chandrakala Yannam, MD [2]
Overview
Disease name] may be caused by [cause1], [cause2], or [cause3].
OR
Common causes of [disease] include [cause1], [cause2], and [cause3].
OR
The most common cause of [disease name] is [cause 1]. Less common causes of [disease name] include [cause 2], [cause 3], and [cause 4].
OR
The cause of [disease name] has not been identified. To review risk factors for the development of [disease name], click here.
Causes
Life-threatening Causes
- Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated. There are no life-threatening causes of disease name, however complications resulting from untreated disease name is common.
- Life-threatening causes of [symptom/manifestation] include [cause1], [cause2], and [cause3].
- [Cause] is a life-threatening cause of [disease].
Common Causes
There following are some of the Common causes of Central Cyanosis:[1]
- Conditions associated with decreased concentration of inspired oxygen (FiO2):
- Smoke inhalation most commonly from house fires
- Carbon monoxide poisoning
- Hydrogen cyanide poisoning
- Intentional or unintensional exposure to asphyxiating gases (eg, Propane, methane, butane, hydrogen sulphide)
- Decresed atmospheric pressure: High altitude
- Disorders associated with impairment of chest wall or lung expansion:
- External compression
- Pneumothorax
- Hemothorax
- Flail chest
- Hypoventilation:
- Upper airway obstruction:
- Foreign body aspiration
- Pertussis / Croup
- Epiglottitis
- Tracheitis mostly bacterial
- Traumatic disruption (burns, fractures)
- Congenital airway abnormalities:
- Choanal atresia
- Laryngotracheomalacia
- Macroglossia
- Micrognathia or retrognathia (eg, Pierre-Robin syndrome)
- Neurologic abnormalities:
- CNS depression
- Severe head trauma
- Apnea of prematurity
- Infections (eg, meningitis, encephalitis)
- Intraventricular hemorrhage
- Seizures
- Cyanotic breath holding spells
- Coma
- Neuromuscular disorders:
- Myasthenia gravis
- Injury to the phrenic nerve
- Type 1 spinal muscular dystrophy (Wernig-Hoffman disease)
- Metabolic disorders:
- Severe hypoglycemia
- In born errors of metabolism
- Upper airway obstruction:
- Ventilation/perfusion mismatch:
- Asthma
- Pulmonary embolism
- Atelectasis
- Alveolar capillary dysplasia
- emphysema or COPD
- Pulmonary edema
- Pulmonary hypoplasia
- Pulmonary hemorrhage
- Respiratory distress syndrome (Hyaline membrane disease)
- Transient tachypnea of the newborn
- Conditions causing impaired oxygen diffusion:
- Pneumonia
- Bronchiolitis
- Bronchopulmonary dysplasia
- Cystic fibrosis
- Empyema
- Circulatory causes:
- Cyanotic congenital heart diseases (Right to left shunts):
- Decreased pulmonary flow:
- Tetralogy of fallot
- Tricuspid valve anomalies:
- Pulmonary stenosis (critical valvular)
- Pulmonary atresia with intact ventricular septum
- Increased pulmonary flow:
- TGA (Transposition of great arteries, most common dextro type)
- Truncus arteriosus
- TAPVC (Total anamalous pulmonary venous connection)
- Heart failure: Condition that present with cyanosis and severe heart failure include:
- Left sided obstructive lesion (HLHS)
- Coarctation of aorta
- Critical valvular aortic stenosis
- Decreased pulmonary flow:
- Eisenmenger syndrome
- Pulmonary causes:
- Pulmonary hypertension
- Pulmonary edema
- Pulmonary hemorrhage
- Pulmonary embolism
- Pulmonary arterio venous malformations
- Multiple small intrapulmonary shunts
- Shock
- Sepsis
- Acute chest syndrome
- Cyanotic congenital heart diseases (Right to left shunts):
- Hematologic abnormalities:
- Methemoglobinemia (congenital or acquired)
- Sulfhemoglobinemia (acquired)
- Hemoglobin mutations with low oxygen affinity: Hb Kansas, Hb Beth israel, Hb Saint Mande, Hb Bruxells
- Polycythemia
- Brief resolved unexplained events (BRUE)
[Disease name] may be caused by:
- [Cause1]
- [Cause2]
- [Cause3]
OR
- [Disease name] is caused by an infection with [pathogen name].
- [Pathogen name] is caused by [pathogen name].
Less Common Causes
Less common causes of disease name include:
- [Cause1]
- [Cause2]
- [Cause3]
Genetic Causes
- [Disease name] is caused by a mutation in the [gene name] gene.
Causes by Organ System
Cardiovascular | No underlying causes
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [3]; Associate Editor(s)-in-Chief: Chandrakala Yannam, MD [4] central cyanosis causes
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