Cyanosis risk factors
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Chandrakala Yannam, MD [2]
Overview
- Common risk factors in the development of cyanosis include congenital heart diseases with right to left shunting, presence of abnormal hemoglobin, carbon monoxide poisoning, respiratory disorders associated with impaired gas exchange, impaired gas diffusion via the alveoli, embolism and ventilation perfusion mismatch, arteriovenous malformations, cold exposure, and raynaud's phenomenon.
Risk Factors
The risk factors for cyanosis include:[1]
- Any condition that interferes with oxygen from entering the alveoli or interrupts its movement across the alveolar interface leads to hypoxemia and cyanosis.
- Decreased inspired oxygen
- Carbon monoxide exposure
- Cyanide poisoning
- Smoke from house fires
- Hypoventilatory disorders:
- Upper airway obstruction
- Foreign body
- Croup
- Epiglottitis
- Bacterial tracheitis
- Traumatic airway disruption
- Congenital airway anomalies
- Neurologic disorders:
- Severe head trauma
- Transient tachypnea of newborn
- Seizures
- BRUE
- Hypoxic ischemic encephalopathy
- Intracranial hemorrhage
- Upper airway obstruction
- Impairment of chest wall or lung expansion
- Intrinsic lung diseases
- Asthma
- COPD
- Pneumonia
- Bronchiolitis
- Empyema
- Impaired alveolar-arterial diffusion: Pulmonary edema
- Ventilation-perfusion mismatch:
- Intracardiac or vascular shunts may cause cyanosis by mixing oxygenated and deoxygenated blood.
- Structural or vascular alteration in pulmonary blood flow
- Cold exposure
- Hemoglobinopathies
- Raynaud's phenomenon
- Altered mental status
- Side effects of pharmacotherapy:
- Beta blockers
- Nitrite or nitrate-containing compounds (eg, nitroglycerin)
- Dapsone
- Sulfonamides
- Benzocaine
- Chloroquine
- High altitude
- Disseminated intravascular coagulation
- Venomous snake bites
- Vaso occlusive crisis (Acute chest syndrome)
- Arterial obstruction:
- Venous obstruction:
- Decreased cardiac output:
- Decreased inspired oxygen