Altitude sickness pathophysiology

Altitude sickness Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Farima Kahe M.D. [2]

Pathophysiology

Abbreviations: CBV= Cerebral blood volume, CBF= Cerebral or coronary blood flow, Pcap= Pulmonary capillary pressure, HACE= High-altitude cerebral edema, HAPE= High-altitude pulmonary edema

Altitude hypoxemia

Brain

Lung

Vasodilation

Uneven vasoconstriction

↑CBV

↑CBF

↑PAP

Overperfusion

Focal/regional overperfusion

↑Pcap

↑Pcap

Vasogenic edema

Capillary leak

HACE

HAPE