Down syndrome risk factors
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Common risk factors involved in the development of Down syndrome include maternal smoking, increased maternal age, impaired recombination of chromosome 21, impaired folate metabolism and oral contraceptive pills (OCPs)
Risk factors
The following are the risk factors for developing Down syndrome:
Common risk factors
Common risk factors in the mother leading to the development of Down syndrome include the following:[1]
- Smoking during pregnancy
- Increased maternal age
- Impaired recombination of chromosome 21
- Impaired folate metabolism
- Oral contraceptive pills (OCPs)
Less common risk factors
Less common risk factors involved in the development of Down syndrome include the following:
- Genomic instability in mothers of Down syndrome patients
- Radiation exposure
- Low socioeconomic status
References
- ↑ Morris JK, Mutton DE, Alberman E (2002). "Revised estimates of the maternal age specific live birth prevalence of Down's syndrome". J Med Screen. 9 (1): 2–6. doi:10.1136/jms.9.1.2. PMID 11943789.