Rheumatoid arthritis causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]
Overview
Causes
The cause of rheumatoid arthritis is idiopathic but genetic, environmental, hormonal, immunologic, infectious factors, socioeconomic, psychological, and lifestyle factors play important role in the development of rheumatoid arthritis.
- Genetic factors:[1]
- In United States, HLA-DR4 cluster(HLA-DR beta *0401, 0404, or 0405,) part of one of the peptide-binding sites of certain HLA-DR molecules associated with rheumatoid arthritis.
- In European countries, HLA-DR1 (HLA-DR beta *0101) is associated with rheumatoid arthritis.
- Infectious agents: Various infectious agents involved in rheumatoid arthritis are:[2][3]
- Mycoplasma
- Epstein-Barr virus (EBV)
- Rubella virus
- Porphyromonas gingivalis
- Hormonal factors:[4]
- Hyperprolactinemia
- Environmental factors:
- Smoking increases the risk of development of rheumatoid arthritis.
- Lifestyle factors:
- Obesity
- Poor health
Causes by Organ System
| Cardiovascular | No underlying causes |
| Chemical/Poisoning | No underlying causes |
| Dental | No underlying causes |
| Dermatologic | No underlying causes |
| Drug Side Effect | No underlying causes |
| Ear Nose Throat | No underlying causes |
| Endocrine | No underlying causes |
| Environmental | No underlying causes |
| Gastroenterologic | No underlying causes |
| Genetic | No underlying causes |
| Hematologic | No underlying causes |
| Iatrogenic | No underlying causes |
| Infectious Disease | No underlying causes |
| Musculoskeletal/Orthopedic | No underlying causes |
| Neurologic | No underlying causes |
| Nutritional/Metabolic | No underlying causes |
| Obstetric/Gynecologic | No underlying causes |
| Oncologic | No underlying causes |
| Ophthalmologic | No underlying causes |
| Overdose/Toxicity | No underlying causes |
| Psychiatric | No underlying causes |
| Pulmonary | No underlying causes |
| Renal/Electrolyte | No underlying causes |
| Rheumatology/Immunology/Allergy | No underlying causes |
| Sexual | No underlying causes |
| Trauma | No underlying causes |
| Urologic | No underlying causes |
| Miscellaneous | No underlying causes |
Causes in Alphabetical Order
List the causes of the disease in alphabetical order.
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3References
- ↑ Barton A, Worthington J (October 2009). "Genetic susceptibility to rheumatoid arthritis: an emerging picture". Arthritis Rheum. 61 (10): 1441–6. doi:10.1002/art.24672. PMID 19790122.
- ↑ Hitchon CA, Chandad F, Ferucci ED, Willemze A, Ioan-Facsinay A, van der Woude D, Markland J, Robinson D, Elias B, Newkirk M, Toes RM, Huizinga TW, El-Gabalawy HS (June 2010). "Antibodies to porphyromonas gingivalis are associated with anticitrullinated protein antibodies in patients with rheumatoid arthritis and their relatives". J. Rheumatol. 37 (6): 1105–12. doi:10.3899/jrheum.091323. PMID 20436074.
- ↑ Routsias JG, Goules JD, Goules A, Charalampakis G, Pikazis D (July 2011). "Autopathogenic correlation of periodontitis and rheumatoid arthritis". Rheumatology (Oxford). 50 (7): 1189–93. doi:10.1093/rheumatology/ker090. PMID 21343168.
- ↑ Barrett JH, Brennan P, Fiddler M, Silman AJ (June 1999). "Does rheumatoid arthritis remit during pregnancy and relapse postpartum? Results from a nationwide study in the United Kingdom performed prospectively from late pregnancy". Arthritis Rheum. 42 (6): 1219–27. doi:10.1002/1529-0131(199906)42:6<1219::AID-ANR19>3.0.CO;2-G. PMID 10366115.