Sjögren's syndrome medical therapy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Farima Kahe M.D. [2]

Overview

Dry eye, dry mouth, and other sicca symptoms:
- Preferred regimen (1): Pilocarpine 5 mg PO q8h
- Preferred regimen (2): Cevimeline 30 mg PO q8h
Organ-based disease and constitutional symptoms:
- Preferred regimen (1): Hydroxychloroquine 5 mg PO q8h
- Preferred regimen (2): Methotrexate 30 mg PO q8h
- Preferred regimen (2): Leflunomide 30 mg PO q8h
- Preferred regimen (2): Azathioprine 30 mg PO q8h
- Preferred regimen (2): Sulfasalazine 30 mg PO q8h
- Preferred regimen (2): Cyclosporine 30 mg PO q8h
- Preferred regimen (2): Cyclophosphamide 30 mg PO q8h
- Preferred regimen (2): Rituximab 30 mg PO q8h