Sjögren's syndrome medical therapy
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Farima Kahe M.D. [2]
Overview
Medical Therapy
- Pharmacologic medical therapies for dry eye, dry mouth, and other sicca symptom of Sjögren's syndrome include:
- Preferred regimen (1): Pilocarpine 5 mg PO q8h
- Preferred regimen (2): Cevimeline 30 mg PO q8h
- Preferred regimen (2): artificial tears
- Pharmacologic medical therapies for organ-based disease and constitutional symptoms of Sjögren's syndrome include:
- Preferred regimen (1): Hydroxychloroquine 200 mg PO q24h
- Preferred regimen (2): Methotrexate 0.2 mg/kg weekly
- Preferred regimen (2): Leflunomide 20 mg/day
- Preferred regimen (3): Azathioprine 3 to 5 mg/kg once daily
- Preferred regimen (4): Sulfasalazine 30 mg PO q8h
- Preferred regimen (5): Cyclosporine 5 mg/kg/day
- Preferred regimen (6): Cyclophosphamide 50-100 mg/m²/day
- Preferred regimen (7): Rituximab 375 mg/m2 once weekly for 4 doses