Henoch-Schönlein purpura natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Complications

The complications of the HSP are as follows:

• Renal involvement- Proteinuria, End Stage Renal Disease in 1% of patients.

• Other complications
  • Myocardial infarction
  • Pulmonary hemorrhage
  • Pleural effusion
  • Intussusception of both small and large intestines
  • Orchitis
  • GI bleeding
  • Bowel infarction
  • Seizures
  • Neuropathies.

Prognosis

• Henoch-Schönlein purpura is an acute self-limited illness, can seldom cause complications.
• Initial attacks of HSP can last for several months. One in every four patients will have one or more recurrences.
• HSP is more benign, short course and less recurrent in children less than three years.
• CKD can progress more than 10 years after the initial HSP attack.
• The long-term prognosis of HSP depends on the extent of the kidney involvement.
• Renal involvement of more common and the prognosis is worst in adults with HSP than the children.