Churg-Strauss syndrome other diagnostic studies
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Bronchoalveolar lavage, Pulmonary function tests and biopsy of lung, skin, kidney, muscle and nerve can be used to diagnose and differentiate eosinophilic granulomatosis with polyangiitis.
Other Diagnostic Studies
The following studies can be helpful in diagnosing eosinophilic granulomatosis with polyangiitis.[1][2]
- Pulmonary function tests:
- Spirometry findings are consistent with asthma.
- Decreased total vital capacity
- Decreased functional vital capacity
- Decreased FEV1/FVC ratio
- Decreased diffusion capacity
- Spirometry findings are consistent with asthma.
- Bronchoalveolar lavage:
- Shows marked eosinophilia. Presence of marked eosinophilia on bronchoalveolar lavage is not specific for the diagnosis of eosinophilic granulomatosis with polyangiitis.
- Biopsy
- Because of the multiple organ involvements, the biopsy should be obtained from any of the following organ sites:
- Biopsy findings may include eosinophilic infiltration, vasculitis of small and medium-sized vessels and granuloma formation.
References
- ↑ Meyer KC, Raghu G, Baughman RP, Brown KK, Costabel U, du Bois RM, Drent M, Haslam PL, Kim DS, Nagai S, Rottoli P, Saltini C, Selman M, Strange C, Wood B (May 2012). "An official American Thoracic Society clinical practice guideline: the clinical utility of bronchoalveolar lavage cellular analysis in interstitial lung disease". Am. J. Respir. Crit. Care Med. 185 (9): 1004–14. doi:10.1164/rccm.201202-0320ST. PMID 22550210.
- ↑ Dunogué B, Pagnoux C, Guillevin L (June 2011). "Churg-strauss syndrome: clinical symptoms, complementary investigations, prognosis and outcome, and treatment". Semin Respir Crit Care Med. 32 (3): 298–309. doi:10.1055/s-0031-1279826. PMID 21674415.
- ↑ Allen JN, Davis WB (1994). "Eosinophilic lung diseases". Am J Respir Crit Care Med. 150 (5 Pt 1): 1423–38. doi:10.1164/ajrccm.150.5.7952571. PMID 7952571.