Undifferentiated connective tissue disease natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Amandeep Singh M.D.[2]
Overview
Natural History, Complications, and Prognosis
Natural History
- The symptoms of undifferentiated connective tissue disease(UCTD)usually are similar to connective tissue diseases but couldn't complete the criteria for their definitive diagnosis.
- If left untreated, 24.3-33% of patients with UCTD may progress to develop manifestations of well defined connective tissue disease such as systemic lupus erythematosus, rheumatoid arthritis, Sjögren's syndrome.[1][2]
Complications
- Common complications of UCTD include:[3]
- Interstitial lung disease- Non specific interstitial pneumonia
Prognosis
- Depending on the extent of the UCTD at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as good.
- The presence of interstitial lung disease is associated with a particularly good prognosis among patients with UCTD rather than being idiopathic.[3]
References
- ↑ Danieli MG, Fraticelli P, Salvi A, Gabrielli A, Danieli G (1998). "Undifferentiated connective tissue disease: natural history and evolution into definite CTD assessed in 84 patients initially diagnosed as early UCTD". Clin. Rheumatol. 17 (3): 195–201. PMID 9694051.
- ↑ Cavazzana I, Franceschini F, Belfiore N, Quinzanini M, Caporali R, Calzavara-Pinton P, Bettoni L, Brucato A, Cattaneo R, Montecucco C (2001). "Undifferentiated connective tissue disease with antibodies to Ro/SSa: clinical features and follow-up of 148 patients". Clin. Exp. Rheumatol. 19 (4): 403–9. PMID 11491495.
- ↑ 3.0 3.1 Kinder BW, Shariat C, Collard HR, Koth LL, Wolters PJ, Golden JA, Panos RJ, King TE (April 2010). "Undifferentiated connective tissue disease-associated interstitial lung disease: changes in lung function". Lung. 188 (2): 143–9. doi:10.1007/s00408-009-9226-7. PMC 2837880. PMID 20069430.