Nephritic syndrome differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Yazan Daaboul, Serge Korjian

Overview

The clinical differentiation between nephritic and nephrotic syndromes is crucial to establish the proper differential diagnosis and determine the appropriate management. In addition, the clinical history and prognosis of nephritic syndrome is different from that of nephrotic syndrome.

Differential Diagnosis

The following table summarizes the key differences between nephrotic syndrome and nephritic syndrome:

Distinguishing Nephritic Syndrome from Nephrotic Syndrome

Clinical Feature	Nephritic Syndrome	Nephrotic Syndrome
Hematuria	Yes	Yes / No
Proteinuria	< 3.5 g/24 hrs	> 3.5 g/24hrs
Red Cell Casts	Yes	No
Hypoalbuminemia	Yes / No	Yes
Hypertension	Yes	Yes / No
Progression	Insidious	Abrupt