Chronic myelogenous leukemia other diagnostic studies
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Chronic myelogenous leukemia Microchapters |
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Differentiating Chronic myelogenous leukemia from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]
Overview
Other diagnostic studies for chronic myelogenous leukemia include bone marrow aspiration and biopsy, lumbar puncture, and lymph node biopsy.
The diagnostic work-up for chronic myelogenous leukemia consists of a complete blood count, including a differential and a platelet count; marrow aspiration, with measurement of the percentage of blasts and the percentage of basophils; marrow biopsy; and cytogenetic studies for Ph and markers of karyotypic evolution. In patients who are Ph negative, molecular studies, such as Southern blot assay or polymerase chain reaction (PCR), are indicated to detect the BCR-ABL rearrangements.PMID:10428738
Other diagnostic studies
Other diagnostic studies for chronic myelogenous leukemia include:[1]
- Used to detect and/or determine the type of leukemic cells
- Used to detect any metastasis to the cerebral spinal fluid (CSF)
- Used to detect and/or determine the type of leukemic cells
Gallery
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![Bone marrow aspiration and biopsy. After a small area of skin is numbed, a Jamshidi needle (a long, hollow needle) is inserted into the patient’s hip bone. Samples of blood, bone, and bone marrow are removed for examination under a microscope.[2]](/images/e/e4/CDR554337-274.jpg)
Bone marrow aspiration and biopsy. After a small area of skin is numbed, a Jamshidi needle (a long, hollow needle) is inserted into the patient’s hip bone. Samples of blood, bone, and bone marrow are removed for examination under a microscope.[2]
![Bone marrow aspiration and biopsy. After a small area of skin is numbed, a Jamshidi needle (a long, hollow needle) is inserted into the patient’s hip bone. Samples of blood, bone, and bone marrow are removed for examination under a microscope.[2]](/index.php/File:CDR554337-274.jpg)
References
- ↑ Canadian Cancer Society.2015.http://www.cancer.ca/en/cancer-information/cancer-type/leukemia-chronic-myelogenous-cml/diagnosis/?region=ab
- ↑ National Cancer Institute. Physician Data Query Database 2015.http://www.cancer.gov/types/leukemia/patient/cml-treatment-pdq