Polyarteritis nodosa laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Cafer Zorkun, M.D., Ph.D. [2]; Haritha Machavarapu, M.B.B.S.

Laboratory Findings

• There are no specific lab tests for diagnosing polyarteritis nodosa.
• Diagnosis is generally based upon the physical examination and a few laboratory studies that help to confirm the diagnosis:

Electrolyte and Biomarker Studies

• CBC (may demonstrate an elevated white blood count)
• ESR (often elevated)
• Perinuclear pattern of antineutrophil cytoplasmic antibodies (p-ANCA) - not associated with "classic" polyarteritis nodosa, but is present in a form of the disease affecting smaller blood vessels, known as microscopic polyangiitis or leukocytoclastic angiitis.
• Elevated c reactive protein