Acid-base imbalance
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2], Priyamvada Singh, M.D. [3]
Overview
Acid-base imbalance has several possible causes. An excess of acid is called acidosis and an excess in bases is called alkalosis. Acidosis is much more common than alkalosis. The imbalance is compensated by negative feedback to restore normal values. Acid-base balance is maintained by normal respiratory and renal excretions of carbon dioxide and acids respectively.
Approach to acid–base imbalance
Check pH on ABG | |||||||||||||||||||||||||||||||||||||||||
pH < 7.35= Acidosis | pH > 7.45= Alkalosis | ||||||||||||||||||||||||||||||||||||||||
Check PaCO2 | |||||||||||||||||||||||||||||||||||||||||
PaCO2 > 45mm Hg = Respiratory acidosis | PaCO2 Normal or < 35mm Hg = Metabolic acidosis | Check PaCO2 | |||||||||||||||||||||||||||||||||||||||
PaCO2 > 45mm Hg = Metabolic alkalosis | PaCO2 < 35mm Hg = Respiratory alkalosis | ||||||||||||||||||||||||||||||||||||||||
[HCO3-] > 29 | Check [HCO3-] | ||||||||||||||||||||||||||||||||||||||||
Normal or slight decrease = Acute respiratory alkalosis | Decreased < 24 = Chronic respiratory alkalosis | ||||||||||||||||||||||||||||||||||||||||
The following steps can help to generate a differential diagnosis on a patient with a suspected acid/base disorder:
- Evaluate the complete clinical picture and laboratory data in patients with suspected acid base disorder.
- Single acid-base disorders are commoner than double acid-base disorders, that are in turn commoner than triple acid-base disorders
- A normal pH doesn't exclude an acid base disorder as a co-existing acidosis and alkalosis can result in a normal pH.
- When the clinical picture raises suspicion of acid-base imbalance and the pH is normal, always check for the anion gap. For e.g. patient with diabetes ketoacidosis (metabolic acidosis) and vomiting (metabloic alkalosis) will present as a normal pH but with elevated anion gaps.
- When the primary disorder is acidosis, the body will compensate by creating an alkalosis (and vice-verse if the primary disorder is an alkalosis). When the primary disorder is respiratory, the body compensate with a metabolic process.
Steps in determining the presence of an acid-base disorder are:
- Check serum pH.
- Normal is 7.40 (7.35-7.45). Values lower than normal represent an acidosis; values higher than normal represent an alkalosis.
- Serum HCO3 drops of 4 to 5 mEq/L (4-5 mmol/L) for each 10 mm Hg (1.3 kPa) decrease in the pCO2[1]
- Check the pCO2 and the HCO3- to decide whether the process is respiratory vs. metabolic.
- Normal serum bicarbonate is 24mEq/dl ; normal serum pCO2 is 40.
- Check the anion gap: serum sodium - (serum chloride plus serum HCO3).
- Normal is 10 mEq/L [10 mmol/L])
- Check for respiratory compensation of metabolic acidosis. Formula for checking appropriate respiratory compensation to metabolic acidosis include:
- Arterial pCO2 = 1.5 x serum HCO3- + 8 ± 2 (Winters' formula)
- Arterial pCO2 = Serum HCO3- + 15
- Arterial pCO2 = (pH − 7) × 100. This is the coincidence rule[2].
- For each increase in the PaCO2 of 10 mmHg, the pH decreases by 0.08.
- Calculate the corrected bicarbonate to check for any coexistent metabolic acidosis (see below delta-delta formula)[3]
- Measure the osmolar gap (online calculator). A high osmolar gap (online calculator) suggestions intoxication with osmotically active agents such as methanol, ethylene glycol, isopropyl alcohol, and toluene.
Coexistent elevated anion gap and normal anion gap metabolic acidosis
- An elevated anion gap can coexist with a normal anion gap metabolic acidosis.
- Delta-Delta equation: Change in anion gap = Change in bicarbonate
- Change in gap (current gap - 12 mEq/L [12 mmol/L])[3]
- Change in bicarb (current bicarb - 24 mEq/L [24 mmol/L])
- If the anion gap increases less and than the serum bicarbonate decreases suggests that there is another metabolic acidosis present, which is decreasing the the serum bicarbonate, but not affecting the anion gap i.e. normal anion gap metabolic acidosis is also present.
Respiratory compensation of metabolic acidosis
- For 1 meq/L fall of serum HCO3- levels there is a 1.2 mmHg fall in arterial pCO2.
- The respiratory compensation of metabolic acidosis is fast and begins within half an hour of metabolic acidosis.
- In cases where the metabolic acidosis develops slowly, the respiratory compensation occurs simultaneously with the metabolic acidosis.
- The respiratory compensation usually completes within 12 to 24 hours
- A failure to develop adequate respiratory response indicates an acute underlying respiratory diseases, neurologic disease or a very acute development of metabolic acidosis.
- Formula for checking appropriate respiratory compensation to metabolic acidosis include:
- Arterial pCO2 = 1.5 x serum HCO3- + 8 ± 2 (Winters' formula)
- Arterial pCO2 = serum HCO3- + 15
- If the measured pCO2 is not close to predicted, a second disorder coexists
- If the pCO2 is less than predicted, respiratory alkalosis is present; if the pCO2 is higher than predicted, respiratory acidosis is present.
- The maximum limit of respiratory compensation for a metabolic acidosis is pCO2 of 20.
Role of the urine anion gap in the patient with a normal anion gap metabolic acidosis
- Urine anion gap helps to differentiate renal tubular acidosis (specifically a Type 1 or Type 4 RTA) from other causes of normal anion gap acidosis.
- The urine anion gap is calculated as the urine sodium plus urine potassium, minus the urine chloride
- Urine anion gap = (Urine Na + Urine K) - Urine Cl
- The pathophysiology behind this is:
- When kidney is exposed to acidosis, the normal response of the kidney is to excrete acid.
- Kidney excretes the excess acid in the form of ammonium, NH4+.
- To maintain neutrality, Cl- is excreted along with ammonium, NH4+.
- Thus, urine chloride act as a surrogate marker for urine ammonium (acidosis)
- In Types 1 and 4 renal tubular acidosis, the kidney's function of acid excretion is compromised (decreased excretion of NH4+ and Cl).
- Thus, in renal tubular acidosis (specifically a Type 1 or Type 4 RTA) urine anion gap will be high (> than zero).
- A urine anion gap less than zero in the normal anion gap metabolic acidosis suggests the kidney is excreting acid, making renal tubular acidosis less likely.
Role of osmolar gap in differential diagnosis of elevated anion gap
- Methanol, ethylene glycol, isopropyl alcohol, toluene are osmotically active substance
- Ingestion of these substances may lead to disturbances that have significant overlap.
- They can be differentiated because of these following characteristics:
- Methanol
- Also called wood alcohol
- Used in antifreeze and solvents
- Presentation: Delirium, papilledema, and retinal hemorrhages
- Elevated anion gap metabolic acidosis
- Ethylene glycol
- Used in antifreeze and solvents
- Presentation: Delirium
- Elevated anion gap metabolic acidosis
- Presence of oxalate crystals in urine
- Isopropyl alcohol
- Also called rubbing alcohol
- No acid-base disorder
- Metabolism causes increase acetone in the blood
- Other conditions with elevated acetones in blood are: diabetes, starvation, and isopropyl alcohol.
- Toluene
- Initial elevated anion gap followed with normal anion gap
- Methanol
- Estimated serum osmolality = (2 * serum sodium + BUN/2.8 + Glucose/18)
Blood Gas Analysis
Venous blood gas sampling should not replace arterial blood gas sampling, but may supplement arterial blood gas monitoring as a mechanism of trending results and minimizing arterial sampling. Central venous blood is preferable to peripheral venous blood, as it more accurately represents the arterial blood gas results. Venous blood is more acidic than arterial blood, so venous pH is lower than arterial pH.
Blood gas analysis | Vessel | Range | Interpretation |
---|---|---|---|
Oxygen Partial Pressure (pO2) | Arterial | 80 to 100 mmHg | Normal |
<80 mmHg | Hypoxia | ||
Venous | 35 to 40 mmHg | Normal | |
Oxygen Saturation (SO2) | Arterial | >95% | Normal |
<95% | Hypoxia | ||
Venous | 70 to 75% | Normal | |
pH | Arterial | <7.35 | Acidemia |
7.35 to 7.45 | Normal | ||
>7.45 | Alkalemia | ||
Venous | 7.26 to 7.46 | Normal | |
Carbon Dioxide Partial Pressure (pCO2) | Arterial | <35 mmHg | Low |
35 to 45 mmHg | Normal | ||
>45 mmHg | High | ||
Venous | 40 to 45 mmHg | Normal | |
Bicarbonate (HCO3−) | Arterial | <22 mmol/L | Low |
22 to 26 mmol/L | Normal | ||
>26 mmol/L | High | ||
Venous | 19 to 28 mmol/L | Normal | |
Base Excess (BE) | Arterial | <−3.4 | Acidemia |
−3.4 to +2.3 mmol/L | Normal | ||
>2.3 | Alkalemia | ||
Venous | −2 to −5 mmol/L | Normal | |
Osmolar gap = Osmolality – Osmolarity | >10 | Abnormal | |
Anion gap = Na+ - [Cl−+ HCO3−] | <8 | Low | |
8 to 16 | Normal | ||
>16 | High |
Relationship between pH and H+
An inverse relationship between the H+ concentration (nmol/L) and the pH is given as follows:[4]
pH | [H+] |
7.80 | 16 |
7.70 | 20 |
7.60 | 26 |
7.50 | 32 |
7.40 | 40 |
7.30 | 50 |
7.20 | 63 |
7.10 | 80 |
7.00 | 100 |
6.90 | 125 |
6.80 | 160 |
Compensation
- There are compensation mechanisms in the body in order to normalizing the pH inside the blood.[5]
- The amount of compensation depends on proper functioning of renal and respiratory systems. However, it is uncommon to compensate completely. Compensatory mechanisms might correct only 50–75% of pH to normal.
- Acute respiratory compensation usually occurs within first day. However, chronic respiratory compensation takes 1 to 4 days to occur.
- Renal compensation might occur slower than respiratory compensation.
Primary disorder | pH | PaCO2 | [HCO3−] | Compensation | Compensation formula |
---|---|---|---|---|---|
Metabolic acidosis | ↓ | ↓ | ↓ | Respiratory |
|
Metabolic alkalosis | ↑ | ↑ | ↑ | Respiratory |
|
Respiratory acidosis | ↓ | ↑ | ↑ | Renal |
|
Respiratory alkalosis | ↑ | ↓ | ↓ | Renal |
|
Mixed Acid−Base Disorders
Disorder | Key features | Examples |
---|---|---|
Metabolic acidosis & respiratory alkalosis |
|
|
Metabolic acidosis & respiratory acidosis |
|
|
Metabolic alkalosis & respiratory alkalosis | ||
Metabolic alkalosis & respiratory acidosis |
| |
Metabolic acidosis & metabolic alkalosis | ||
Metabolic acidosis & metabolic acidosis |
|
Related Chapters
- Metabolic alkalosis
- Respiratory alkalosis
- Metabolic acidosis
- Respiratory acidosis
- Anion gap
- Hypocalcemia
References
- ↑ American College of Physicians. Medical Knowledge Self-Assessment Program
- ↑ Liu GS, Bhalla V (2017). "Explaining the Coincidence Rule for Estimating Respiratory Compensation in Metabolic Acid-Base Disorders". Ann Intern Med. 166 (8): 610. doi:10.7326/L16-0470. PMID 28384697.
- ↑ 3.0 3.1 Goodkin DA, Krishna GG, Narins RG (1984). "The role of the anion gap in detecting and managing mixed metabolic acid-base disorders". Clin Endocrinol Metab. 13 (2): 333–49. PMID 6488577.
- ↑ Rose, Burton David; Post, Theodore W. (2001). Clinical physiology of acid-base and electrolyte disorder. New York: McGraw-Hill. ISBN 0-07-134682-1.
- ↑ Sood P, Paul G, Puri S (April 2010). "Interpretation of arterial blood gas". Indian J Crit Care Med. 14 (2): 57–64. doi:10.4103/0972-5229.68215. PMC 2936733. PMID 20859488.