Polycystic kidney disease epidemiology and demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Serge Korjian, Yazan Daaboul
Overview
ADPKD affects approximately 1 in 1000 individuals although prevalence varies according to countries and certain microsattelite regions with a heavy concentration of PKD mutations.
Epidemiology and Demographics
Incidence
- The incidence/prevalence of [disease name] is approximately [number range] per 100,000 individuals in the United States.
- In 1957, the incidence/prevalence of [disease name] was estimated to be [number range] cases per 100,000 individuals worldwide.
Prevalence
- The prevalence of polycystic kidney disease is approximately 100 - 250 per 100,000 individuals in the United States.[1][2]
- In 2013, the prevalence of polycystic kidney disease was estimated to be 33 cases per 100,000 individuals in Germany.[3]
- In 1998, the prevalence of polycystic kidney disease was estimated to be 25 cases per 100,000 individuals in Japan.[4]
- In 1996, the prevalence of polycystic kidney disease was estimated to be 90 cases per 100,000 individuals in France.[5]
- In 1991, the prevalence of polycystic kidney disease was estimated to be 41 cases per 100,000 individuals in United Kingdom.[6]
- In 1957, the prevalence of polycystic kidney disease was estimated to be 100 cases per 100,000 individuals in Denmark.[7]
- The prevalence of [disease/malignancy] is estimated to be [number] cases annually.
Case-fatality rate/Mortality rate
- In [year], the incidence of [disease name] is approximately [number range] per 100,000 individuals with a case-fatality rate/mortality rate of [number range]%.
- The case-fatality rate/mortality rate of [disease name] is approximately [number range].
Age
- Patients of all age groups may develop [disease name].
- The incidence of [disease name] increases with age; the median age at diagnosis is [#] years.
- [Disease name] commonly affects individuals younger than/older than [number of years] years of age.
- [Chronic disease name] is usually first diagnosed among [age group].
- [Acute disease name] commonly affects [age group].
Race
- There is no racial predilection to [disease name].
- [Disease name] usually affects individuals of the [race 1] race. [Race 2] individuals are less likely to develop [disease name].
Gender
- [Disease name] affects men and women equally.
- [Gender 1] are more commonly affected by [disease name] than [gender 2]. The [gender 1] to [gender 2] ratio is approximately [number > 1] to 1.
Region
- The majority of [disease name] cases are reported in [geographical region].
- [Disease name] is a common/rare disease that tends to affect [patient population 1] and [patient population 2].
Developed Countries
Developing Countries
ADPKD is a disorder found worldwide and in all ethnic groups. Prevalence is slightly lower in African Americans with fewer cases of ESRD attributed to ADPKD than in Caucasian or Asian individuals. Prevalence is roughly equal among males and females. The table below summarizes the estimated prevalence in selected countries based on available epidemiologic studies.[8]
| Country | Prevalence | Article |
| USA | 1 in 400-1000 | Iglesias et al, 1983[1] |
| Denmark | 1 in 1000 | Dalgaard, 1957[7] |
| Germany | 1 in 3058 | Neumann et al, 2013[3] |
| France | 1 in 1111 | Simon et al, 1996[5] |
| United Kingdom | 1 in 2459 | Davies et al, 1991[6] |
| Japan | 1 in 4033 | Higashihara et al, 1998[4] |
References
- ↑ 1.0 1.1 Iglesias CG, Torres VE, Offord KP, Holley KE, Beard CM, Kurland LT (1983). "Epidemiology of adult polycystic kidney disease, Olmsted County, Minnesota: 1935-1980". Am J Kidney Dis. 2 (6): 630–9. PMID 6846334.
- ↑ Gabow PA (July 1993). "Autosomal dominant polycystic kidney disease". N. Engl. J. Med. 329 (5): 332–42. doi:10.1056/NEJM199307293290508. PMID 8321262.
- ↑ 3.0 3.1 Neumann HP, Jilg C, Bacher J, Nabulsi Z, Malinoc A, Hummel B; et al. (2013). "Epidemiology of autosomal-dominant polycystic kidney disease: an in-depth clinical study for south-western Germany". Nephrol Dial Transplant. 28 (6): 1472–87. doi:10.1093/ndt/gfs551. PMID 23300259.
- ↑ 4.0 4.1 Higashihara E, Nutahara K, Kojima M, Tamakoshi A, Yoshiyuki O, Sakai H; et al. (1998). "Prevalence and renal prognosis of diagnosed autosomal dominant polycystic kidney disease in Japan". Nephron. 80 (4): 421–7. PMID 9832641.
- ↑ 5.0 5.1 Simon P, Le Goff JY, Ang KS, Charasse C, Le Cacheux P, Cam G (1996). "[Epidemiologic data, clinical and prognostic features of autosomal dominant polycystic kidney disease in a French region]". Nephrologie. 17 (2): 123–30. PMID 8838759.
- ↑ 6.0 6.1 Davies F, Coles GA, Harper PS, Williams AJ, Evans C, Cochlin D (1991). "Polycystic kidney disease re-evaluated: a population-based study". Q J Med. 79 (290): 477–85. PMID 1946928.
- ↑ 7.0 7.1 DALGAARD OZ (1957). "Bilateral polycystic disease of the kidneys; a follow-up of two hundred and eighty-four patients and their families". Acta Med Scand Suppl. 328: 1–255. PMID 13469269 Check
|pmid=value (help). - ↑ Torres VE, Harris PC, Pirson Y (2007). "Autosomal dominant polycystic kidney disease". Lancet. 369 (9569): 1287–301. doi:10.1016/S0140-6736(07)60601-1. PMID 17434405.