Myeloproliferative neoplasm causes

Myeloproliferative Neoplasm Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2] Shyam Patel [3]

Overview

Myeloproliferative neoplasm is caused by mutations in various genes. Different gene mutations are responsible for each of the 8 subtypes of myeloproliferative neoplasms.

Causes

Myeloproliferative neoplasm subtype	Causative gene mutation
Polycythemia vera	JAK2 V617F in 95% of cases CALR MPL
Essential thrombocythemia	JAK2 V617F in 50-60% of cases CALR MPL
Primary myelofibrosis	JAK2 V617F in 50-60% of cases CALR MPL
Chronic myeloid leukemia	BCR-ABL SETBP1
Chronic neutrophilic leukemia	CSF3R
Chronic eosinophilic leukemia	FIL1L1-PDGFRA PDGFRB FGFR1 PCM1-JAK2
Myeloproliferative neoplasm, unclassifiable	Variable
Mastocytosis	c-kit D816V