Diffuse large B cell lymphoma laboratory tests

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DLBCL require a complete work-up includes immunophenotypic analysis, cytogenetic analysis (conventional methods and FISH), and molecular diagnostic assays.

Laboratory tests of diffuse large B cell lymphoma include:

• Complete blood count (CBC)
• Blood chemistry studies including LDH and Uric acid
• Flow cytometry
• Immunohistochemistry
• Cytology (for primary CNS lymphoma only)
• Genetic testing
  • 8q24/MYC translocations
  • Immunoglobulin genes clonally rearranged and hypermutated
  • Mutation of BCL6, MYC, PAX5, PIM1, RhoH/TTFn, TP53 genes
  • Translocations involving c-MYC, BCL6, and IgH genes

• Immunophenotyping
  • BCL-2+, BCL6+/-, MYC, CD5, CD10+, CD15+, CD20+, CD22+, CD30+, CD79a+, EBNA-2+, Fox-P1+, IRF4/MUM1+, P53, LMP-1+, Surface 4 or cytoplasmic immunoglobulin (Ig) is absent
• Screening tests for HIV, HBV and HCV are recommended.

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