Post-streptococcal glomerulonephritis laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]
Overview
Laboratory findings consistent with the diagnosis of streptococcal infection include antistreptolysin O (ASO) positive, antinicotinamide adenine dinucleotides positive, antihyaluronidase, and anti–DNAse B positive. Other abnormal laboratory findings include leukocytosis with neutrophilia, CRP is raised, increased levels of blood urea nitrogen (BUN) and serum creatinine levels are increased.
Laboratory Findings
- Diagnosis of preceding streptococcal infection can be determined by measuring following antibodies:[1]
- The antistreptolysin O (ASO) positive
- Antinicotinamide adenine dinucleotides (anti-NAD) positive
- Antihyaluronidase (AHase), and anti–DNAse B positive
- CBC with differential count:[2]
- Leukocytosis with neutrophilia
- CRP is raised
- Renal function tests:
- Increased levels of blood urea nitrogen (BUN)
- Serum creatinine levels are increased
- Serologic testing:[3][4]
- Hypocomplementemia such as low serum level of C3, C4, and C5.
- Urinalysis:[5]
- Proteinuria
- Hematuria
- Urine sediments show red blood cells, red blood cell casts, white blood cells, granular casts
- Dysmorphic red blood cells are characteristics findings of glomerular hematuria
References
- ↑ Lang MM, Towers C (August 2001). "Identifying poststreptococcal glomerulonephritis". Nurse Pract. 26 (8): 34, 37–42, 44–7, quiz 48–9. PMID 11521409.
- ↑ Kılıc BD, Kara MA, Buyukcelik M, Balat A (May 2018). "Evaluation of clinical and laboratory findings in pediatric post-streptococcal glomerulonephritis". Pediatr Int. doi:10.1111/ped.13587. PMID 29729114.
- ↑ Wyatt RJ, Forristal J, West CD, Sugimoto S, Curd JG (April 1988). "Complement profiles in acute post-streptococcal glomerulonephritis". Pediatr. Nephrol. 2 (2): 219–23. PMID 3153014.
- ↑ Cameron JS, Vick RM, Ogg CS, Seymour WM, Chantler C, Turner DR (September 1973). "Plasma C3 and C4 concentrations in management of glomerulonephritis". Br Med J. 3 (5882): 668–72. PMC 1587021. PMID 4200478.
- ↑ Luo C, Chen D, Tang Z, Zhou Y, Wang J, Liu Z, Li L (September 2010). "Clinicopathological features and prognosis of Chinese patients with acute post-streptococcal glomerulonephritis". Nephrology (Carlton). 15 (6): 625–31. doi:10.1111/j.1440-1797.2010.01352.x. PMID 20883283.