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Leiomyosarcoma classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

Leiomyosarcoma may be classified according to location of the tumor, prognosis and possible treatments into four group:

• Leiomyosarcoma of Soft Tissue Retroperitoneal Somatic soft tissue

• Leiomyosarcoma of Cutaneous Origin
• Leiomyosarcoma of Vascular Origin (large vessel)
• Leiomyosarcoma in the Immunocompromised Host
• Leiomyosarcoma of Bone

While many staging systems exist for Leiomyosarcoma, the most commonly used system is the AJCC system.Leiomyosarcoma staging can also be done according to The Surgical Staging System of the Musculoskeletal Tumor Society (MSTS).Staging of leiomyosarcoma is important both in guiding treatment and in providing prognostic information.

Classification

Leiomyosarcoma may be classified according to location of the tumor, prognosis and possible treatments into four group:

• Leiomyosarcoma of Soft Tissue Retroperitoneal Somatic soft tissue

• Leiomyosarcoma of Cutaneous Origin
• Leiomyosarcoma of Vascular Origin (large vessel)
• Leiomyosarcoma in the Immunocompromised Host
• Leiomyosarcoma of Bone

Staging

Although many staging system exist for the soft tissue sarcoma but the most commonly used system is the AJCC system.This system classifies the tumor based upon histological grade, the tumor size, location as superficial or deep, and the presence or absence of metastatic disease

Stage	Histological Grade	Size	Location, relative to fascia	Metastasis
IA	Low	< 5cm	Superficial or Deep	No
IB	Low	≥ 5cm	Superficial	No
IIA	Low	≥ 5cm	Deep	No
IIB	High	< 5cm	Superficial or Deep	No
IIC	High	≥ 5cm	Superficial	No
III	High	≥ 5cm	Deep	No
IV	Any	Any	Any	Yes

Leiomyosarcoma staging can also be done according to The Surgical Staging System of the Musculoskeletal Tumor Society (MSTS).This staging system classifies tumors as Ia, Ib, IIa, IIb, or III based upon the histologic grade of the tumor, its local extent and the presence or absences of macroscopic distant metastatic disease. If the tumor is localized to a single anatomic compartment, it is said to be confined. If it has spread locally beyond its initial compartment, then it is said to be unconfined.

Stage	Histological Grade	Local Extent of Disease	Metastasis
Ia	Low	Confined	No
Ib	Low	Unconfined	No
IIa	High	Confined	No
IIb	High	Unconfined	No
III	Any	Any	Yes

References

"Leiomyosarcoma Cancer: Diagnosis, Treatment, Research & Support".