Wilms' tumor epidemiology and demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sargun Singh Walia M.B.B.S.[2]Shanshan Cen, M.D. [3]
Overview
Wilms tumors are the most common pediatric renal mass. The incidence of Wilms tumor is estimated to be 0.71 cases per 10,00,000 children younger than 15 years. There is no significant gender predilection among unilateral cases, but the male to female ratio in bilateral cases is 0.60:1.00. It typically occurs in early childhood with peak incidence between 3 and 4 years of age. Asian individuals are less likely to develop Wilms tumor.
Epidemiology and Demographics
Prevalence
- Wilms tumours are the most common paediatic renal mass, accounting for over 85% of cases and accounts for 6% of all childhood cancers.[1]
Incidence
- The incidence of Wilms tumor is 7.1 cases per 1 million children younger than 15 years.[2]
- Approximately 500 cases of Wilms tumor are diagnosed in the United States each year.[3]
Age
- It typically occurs in early childhood (1-11 years) with peak incidence between 3 and 4 years of age.
- Approximately 80% of these tumors are found before the age of 5 years.
- When part of a syndrome they occur even earlier, typically between 2 and 24 months of age.[4]
- The mean age at diagnosis is 44 months in unilateral cases of Wilms tumor and 31 months in bilateral cases.
Sex
- The male to female ratio in unilateral cases of Wilms tumor is 0.92:1.00, but in bilateral cases it is 0.60:1.00.
Race
- The incidence is substantially lower in Asians.
References
- ↑ Wallenstein G, Rebohle E, Voigt U, Schneider WD, Bergmann I (August 1976). "[Trypsin-inhibitory - capacity in humans to respirable allergens or irritants (author's transl)]". Z Erkr Atmungsorgane (in German). 146 (2): 120–7. PMID 65842.
- ↑ Morimoto T (January 1970). "[Circadian rhythm of urine composition and kidney function]". Nippon Rinsho (in Japanese). 28 (1): 193–5. PMID 5461897.
- ↑ National Cancer Institute. Physician Data Query Database 2015. http://www.cancer.gov/publications/pdq
- ↑ Wilms tumour. Dr Tim Luijkx and Dr Frank Gaillard et al. Radiopaedia.org 2015.http://radiopaedia.org/articles/wilms-tumour