Multiple myeloma other diagnostic studies
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
Cytology and/or histology, cytogenetic investigation (chromosome analysis and FISH) may be helpful in the diagnosis of multiple myeloma to detect unfavorable cytogenetic aberrations.[1] PMID:27476706 On bone marrow biopsy, multiple myeloma is characterized by an increase in percentage of abnormal plasma cells.[1] On genetic testing, multiple myeloma is characterized by chromosome 13 deletion and chromosome 14 translocation.[1][2]
Bone Marrow Biopsy
- Bone marrow biopsy is usually performed to estimate the percentage of bone marrow occupied by plasma cells.[1]
- Examination of abnormal plasma in the bone marrow is the only way to confirm a diagnosis.[1]
- The percentage of plasma cells is also used in the diagnostic criteria of multiple myeloma.[1]
Cytogenetic Tests
- Detects any chromosomal mutations occurring in multiple myeloma such as chromosome 13 deletion.[1][2]
Fluorescent in situ hybridization (FISH)
- Detects any chromosomal mutations occurring in multiple myeloma such as chromosome 14 translocation.<[1][2]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Multiple myeloma. Canadian Cancer Society(2015) http://www.cancer.ca/en/cancer-information/cancer-type/multiple-myeloma/diagnosis/?region=mb#blood_chem Accessed on September, 20th 2015
- ↑ 2.0 2.1 2.2 Multiple myeloma. Wikipedia (2015)https://en.wikipedia.org/wiki/Multiple_myeloma#Pathophysiology Accessed on September 2015