Membranous glomerulonephritis laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Syed Ahsan Hussain, M.D.[2]
Overview
- The major laboratory workup includes blood workup, auto-immune workup and urine workup.
Laboratory Findings
- The laboratory workup of membranous glomerulonephritis includes blood, urine and anti-bodies workup. [1] [2]
- Comprehensive chemistry panel including serum albumin
- Complete blood count
- Urinalysis with examination of the sediment
- 24-hour urine collection for protein quantification and creatinine clearance
- ANA and, if positive, anti-double-stranded DNA (anti-dsDNA), anti-Sm, anti-Ro/SSA, and anti-La/SSB antibodies
- Tests for hepatitis B and C viruses and the human immunodeficiency virus (HIV) (see "Hepatitis B virus: Screening and diagnosis", section on 'Diagnostic algorithms' and "Diagnosis and evaluation of chronic hepatitis C virus infection", section on 'Testing algorithm' and "Screening and diagnostic testing for HIV infection", section on 'Testing algorithm')
- Serum C3 and C4 complement levels
- In patients older than 50 years – serum free light chains (SFLCs) and serum protein electrophoresis (SPEP) with immunofixation
- Chest radiograph (or computed tomography [CT] of the chest in patients with a history of smoking or asbestos exposure)
- Anti-PLA2R antibody (by enzyme-linked immunosorbent assay [ELISA])
References
- ↑ Qin W, Beck LH, Zeng C, Chen Z, Li S, Zuo K, Salant DJ, Liu Z (June 2011). "Anti-phospholipase A2 receptor antibody in membranous nephropathy". J. Am. Soc. Nephrol. 22 (6): 1137–43. doi:10.1681/ASN.2010090967. PMC 3103733. PMID 21566055.
- ↑ Hofstra JM, Debiec H, Short CD, Pellé T, Kleta R, Mathieson PW, Ronco P, Brenchley PE, Wetzels JF (October 2012). "Antiphospholipase A2 receptor antibody titer and subclass in idiopathic membranous nephropathy". J. Am. Soc. Nephrol. 23 (10): 1735–43. doi:10.1681/ASN.2012030242. PMC 3458465. PMID 22956816.