Membranous glomerulonephritis laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Syed Ahsan Hussain, M.D.[2]
Overview
- The major laboratory workup includes blood workup, auto-immune workup and urine workup
Laboratory Findings
- The laboratory workup of membranous glomerulonephritis includes blood, urine and anti-bodies workup[1][2]
- Comprehensive chemistry panel including serum albumin
- Complete blood count
- Urinalysis with examination of the sediment
- 24-hour urine collection for protein quantification and creatinine clearance
- ANA and, if positive, anti-double-stranded DNA (antids-DNA), anti-Sm, anti-Ro/SSA, and anti-La/SSB antibodies to rule out autoimmune disease (SLE)
- Tests for hepatitis B and C viruses and the human immunodeficiency virus (HIV)
- Serum C3 and C4 complement levels
- Serum free light chains (SFLCs) and serum protein electrophoresis (SPEP) with immunofixation
- Anti-PLA2R antibody by enzyme-linked immunosorbent assay (ELISA)
References
- ↑ Qin W, Beck LH, Zeng C, Chen Z, Li S, Zuo K, Salant DJ, Liu Z (June 2011). "Anti-phospholipase A2 receptor antibody in membranous nephropathy". J. Am. Soc. Nephrol. 22 (6): 1137–43. doi:10.1681/ASN.2010090967. PMC 3103733. PMID 21566055.
- ↑ Hofstra JM, Debiec H, Short CD, Pellé T, Kleta R, Mathieson PW, Ronco P, Brenchley PE, Wetzels JF (October 2012). "Antiphospholipase A2 receptor antibody titer and subclass in idiopathic membranous nephropathy". J. Am. Soc. Nephrol. 23 (10): 1735–43. doi:10.1681/ASN.2012030242. PMC 3458465. PMID 22956816.