Glanzmann's thrombasthenia physical examination

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Glanzmann's thrombasthenia

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Patients with Glanzmann’s thrombasthenia may be asymptomatic, or they could manifest mucosal bleeding, ecchymoses,petechiae and purpura or current bleeding on physical exam.[1]

Physical examination

Appearance of the Patient

  • Patient appears well in the the absence of severe hemorrhage
  • Patient appears ill in the persistent bleeding .

Vital Signs

  • may haveTachycardia, depends on the severity of the bleeding.
  • may haveTachypnea depends on severity of the bleeding

Skin

HEENT

  • Abnormalities of the head may include
  • Evidence of trauma
  • pale conjunctiva
  • Epistaxis
  • palatal petechiae,
  • gingival or other oral bleeding.

Neck

No specific sign.

Lungs

  • commonly normal lung sounds.

Heart

  • commonly normal heart sounds

Abdomen

The spleen is usually non palpable.

Neuromuscular

  • Patient is usually oriented to persons, place, and time
  • Glasgow coma scale is normally 15 / 15 but may may present loss of consciousness in severe fatal hemorrhage episodes. [2]

Gallery

Extremities

References

  1. Nurden AT, Pillois X, Wilcox DA (2013). "Glanzmann thrombasthenia: state of the art and future directions". Semin Thromb Hemost. 39 (6): 642–55. doi:10.1055/s-0033-1353393. PMC 4011384. PMID 23929305.
  2. Nurden AT (2006). "Glanzmann thrombasthenia". Orphanet J Rare Dis. 1: 10. doi:10.1186/1750-1172-1-10. PMC 1475837. PMID 16722529.
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 "Dermatology Atlas".