Membranous glomerulonephritis natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Syed Ahsan Hussain, M.D.[2]
Overview
The symptoms of membranous glomerulonephritis usually develop in the fourth decade of life in males. Common complications of membranous glomerulonephritis include renal failure. The prognosis is generally good.
Natural History
- The natural history of membranous glomerulonephritis is given below:[1][2]
- The symptoms of membranous glomerulonephritis usually develop in the fourth decade of life in males.
- The symptoms of membranous glomerulonephritis typically develop in young women increases the susceptibility of lupus.
- 5-30% patients have spontanous remission.
Complications
- Common complications of membranous glomerulonepharitis include:
Prognosis
- The prognostic factors of membranous glomerulonephritis are given below:[4][5]
- Prognosis is generally good, and 1 year mortality rate of patients with membranous glomerulonephritis is approximately 0.38%.
- Depending on the extent of the membranous glomerulonephritis at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as good.
- The presence of proteinuria and baseline renal insuffiency are associated with a particularly poor prognosis among patients with membranous glomerulonephritis.
- Membranous glomerulonephritis is associated with the most favorable prognosis.
- The prognosis of membranous glomerulonephritis associated with hepatitis B has less favorable prognosis.
References
- ↑ Kerjaschki D (2000). "Pathogenetic concepts of membranous glomerulopathy (MGN)". J. Nephrol. 13 Suppl 3: S96–100. PMID 11132040.
- ↑ Schieppati A, Mosconi L, Perna A, Mecca G, Bertani T, Garattini S, Remuzzi G (July 1993). "Prognosis of untreated patients with idiopathic membranous nephropathy". N. Engl. J. Med. 329 (2): 85–9. doi:10.1056/NEJM199307083290203. PMID 8510707.
- ↑ Debiec H, Ronco P (July 2014). "Immunopathogenesis of membranous nephropathy: an update". Semin Immunopathol. 36 (4): 381–97. doi:10.1007/s00281-014-0423-y. PMID 24715030.
- ↑ Wasserstein AG (April 1997). "Membranous glomerulonephritis". J. Am. Soc. Nephrol. 8 (4): 664–74. PMID 10495797.
- ↑ McGrogan, A.; Franssen, C. F. M.; de Vries, C. S. (2010). "The incidence of primary glomerulonephritis worldwide: a systematic review of the literature". Nephrology Dialysis Transplantation. 26 (2): 414–430. doi:10.1093/ndt/gfq665. ISSN 0931-0509.