Myoglobinuria
For patient information, click here
|
Myoglobinuria Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Myoglobinuria On the Web |
|
American Roentgen Ray Society Images of Myoglobinuria |
| Myoglobinuria | |
 | |
|---|---|
| Model of helical domains in myoglobin. |
|
WikiDoc Resources for Myoglobinuria |
|
Articles |
|---|
|
Most recent articles on Myoglobinuria Most cited articles on Myoglobinuria |
|
Media |
|
Powerpoint slides on Myoglobinuria |
|
Evidence Based Medicine |
|
Clinical Trials |
|
Ongoing Trials on Myoglobinuria at Clinical Trials.gov Trial results on Myoglobinuria Clinical Trials on Myoglobinuria at Google
|
|
Guidelines / Policies / Govt |
|
US National Guidelines Clearinghouse on Myoglobinuria NICE Guidance on Myoglobinuria
|
|
Books |
|
News |
|
Commentary |
|
Definitions |
|
Patient Resources / Community |
|
Patient resources on Myoglobinuria Discussion groups on Myoglobinuria Patient Handouts on Myoglobinuria Directions to Hospitals Treating Myoglobinuria Risk calculators and risk factors for Myoglobinuria
|
|
Healthcare Provider Resources |
|
Causes & Risk Factors for Myoglobinuria |
|
Continuing Medical Education (CME) |
|
International |
|
|
|
Business |
|
Experimental / Informatics |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aksiniya Stevasarova, M.D.; Venkata Sivakrishna Kumar Pulivarthi M.B.B.S [2]
Overview
Myoglobinuria is the presence of myoglobin in the urine, usually associated with rhabdomyolysis or muscle destruction.
- Myoglobin (Mb or MB) is an iron- and oxygen-binding protein found in muscles. Myoglobin is present in muscle cells as a reserve of oxygen.In humans, myoglobin is only found in the bloodstream after muscle injury. It is an abnormal finding, and can be diagnostically relevant when found in blood.[1]
- Myoglobin is the primary oxygen-carrying pigment of muscle tissues.[2] High concentrations of myoglobin in muscle cells allow organisms to hold their breath for a longer period of time. Diving mammals such as whales and seals have muscles with particularly high abundance of myoglobin.[1] Myoglobin is found in Type I muscle, Type II A and Type II B, but most texts consider myoglobin not to be found in smooth muscle.
References
- ↑ 1.0 1.1 Nelson DL, Cox MM (2000). Lehninger Principles of Biochemistry (3rd ed.). New York: Worth Publishers. p. 206. ISBN 0-7167-6203-X. (Google books link is the 2008 edition)
- ↑ Ordway GA, Garry DJ (Sep 2004). "Myoglobin: an essential hemoprotein in striated muscle". The Journal of Experimental Biology. 207 (Pt 20): 3441–6. doi:10.1242/jeb.01172. PMID 15339940.
Historical Perspective
Myoglobin was the first protein to have its three-dimensional structure revealed by X-ray crystallography.[1] This achievement was reported in 1958 by John Kendrew and associates.[2] For this discovery, John Kendrew shared the 1962 Nobel Prize in chemistry with Max Perutz.[3] Despite being one of the most studied proteins in biology, its physiological function is not yet conclusively established: mice genetically engineered to lack myoglobin can be viable and fertile but show many cellular and physiological adaptations to overcome the loss. Through observing these changes in myoglobin-deplete mice, it is hypothesised that myoglobin function relates to increased oxygen transport to muscle, oxygen storage and as a scavenger of reactive oxygen species.[4]
References
- ↑ (U.S.) National Science Foundation: Protein Data Bank Chronology (Jan. 21, 2004). Retrieved 3.17.2010
- ↑ Kendrew JC, Bodo G, Dintzis HM, Parrish RG, Wyckoff H, Phillips DC (Mar 1958). "A three-dimensional model of the myoglobin molecule obtained by x-ray analysis". Nature. 181 (4610): 662–6. Bibcode:1958Natur.181..662K. doi:10.1038/181662a0. PMID 13517261.
- ↑ The Nobel Prize in Chemistry 1962
- ↑ Garry DJ, Kanatous SB, Mammen PP (2007). "Molecular insights into the functional role of myoglobin". Advances in Experimental Medicine and Biology. 618: 181–93. doi:10.1007/978-0-387-75434-5_14. PMID 18269197.
Classification
Pathophysiology
Causes
Differentiating Lead poisoning from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic study of choice | History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | X-Ray Findings | Echocardiography and Ultrasound | CT-Scan Findings | MRI Findings | Other Imaging Findings | Other Diagnostic Studies
Treatment
Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies