Pseudotumor cerebri differential diagnosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Differentiating [Disease name] from other Diseases
Pseudotumor cerebri must be differentiated from other diseases that cause increased intracranial pressure:
Secondary intracranial hypertension
- Intracranial mass lesions (tumor, abscess)
- Obstruction of venous outflow, eg, venous sinus thrombosis, jugular vein compression, neck surgery
- Obstructive hydrocephalus
- Decreased CSF absorption, eg, arachnoid granulation adhesions after bacterial or other infectious
- meningitis, subarachnoid hemorrhage
- Increased cerebrospinal fluid (CSF) production, eg, choroid plexus papilloma
- Malignant systemic hypertension
Most of these condition can be ruled out by imaging techniques like MRI, CT scan and MR venography.(83-85 uptodate clinical and diagnosis)
Bilateral disc abnormalities
- Pseudopapilledema: Some non-diseased conditions like congenital disc abnormalities ( drusen and myelinated nerve fibers), farsightedness and hyperopia can cause the appearance of papilledema(29-30 upto ddx papill)
- Malignant hypertention: Severe systemic hypertension can mimic papilledema but it also cause other signs like hemorrhages, exudates, cotton wool spots, diplopia, scotomata and photopsia which help us differentiate it from other causes of papilledema.(32-33-34 upto ddx papilledema)
- Diabetic papillopathy: Diabetic papillopathy can mimic papilledema from increased instracranial pressure with telangiectasias, hemorrhages and macular star.(35 upto ddx papilledema)
- Hyperviscosity, hypotension, and blood loss (39 uptodate ddx papilledema)
- Toxic optic neuropathies: methanol, ethambutol and ethylene glycol can cause papilledema early in their course.(9 uptodate ddx papilledema)
Refrences
| Diseases | Clinical manifestations | Para-clinical findings | Gold standard | Additional findings | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Symptoms | Physical examination | ||||||||||||||
| Lab Findings | Imaging | Histopathology | |||||||||||||
| Symptom 1 | Symptom 2 | Symptom 3 | Physical exam 1 | Physical exam 2 | Physical exam 3 | Lab 1 | Lab 2 | Lab 3 | Imaging 1 | Imaging 2 | Imaging 3 | ||||
| Differential Diagnosis 1 | |||||||||||||||
| Differential Diagnosis 2 | |||||||||||||||
| Differential Diagnosis 3 | |||||||||||||||
| Diseases | Symptom 1 | Symptom 2 | Symptom 3 | Physical exam 1 | Physical exam 2 | Physical exam 3 | Lab 1 | Lab 2 | Lab 3 | Imaging 1 | Imaging 2 | Imaging 3 | Histopathology | Gold standard | Additional findings |
| Differential Diagnosis 4 | |||||||||||||||
| Differential Diagnosis 5 | |||||||||||||||
| Differential Diagnosis 6 | |||||||||||||||