Pseudotumor cerebri natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Natural History, Complications, and Prognosis
Natural History
The symptoms of pseudotumor cerebri usually develop in the mean age of 31 mostly in obese women with headache as the most common presenting sign. the other symtoms of increased intracranial pressure may develop in patients sych as ==== Headache (84 to 92 percent): ==== Headache is the most common presenting symptom of pseudotumore cerebri[1] and can be very variable in character. The headache can be lateralized, throbbing or pulsatile, intermittent or persistent and with or without nausea and vomiting. The headache can mimic migraine or tension headaches and can be exacerbate with change in posture. The headaches can follow a nerve root distribution (trigeminal or cervical nerve roots).[2]
visual symptoms(68 to 72 percent):
Transient visual obscuration can be rarely present in one group and frequently in another one. This symptom is unilateral or bilateral and can be provoked by change in position like standing up or bending over and also with valsalva maneuver, bright light and eye movement.[1][3]
Intracranial noises (pulsatile tinnitus) (52 to 60 percent):
Pulse synchronous tinnitus is very suggestive of IIH especially when it happens during headache periods. The reason of this voice is believed to be the vascular pulsation transmitted by high pressure CSF to the venous sinuses.[3][4]
Photopsia (48 to 54 percent):
Photopsias which defines as seeing flashes of light or sparkles may also be present in the course of IIH disease and can be exacerbate with change in position[3]
Back pain (53 percent):
These patients commonly report neck and back pain and stiffness.[1][5]
Retrobulbar pain (44 percent):
The most specific headache feature in IIH patients is retrobulbar pain with eye movement or glob compression[2]
Diplopia (18 to 38 percent):
Intermittent or continuous horizontal diplopia can occur in IIH patients in the result of abducens palsy.[6]
Sustained visual loss (26 to 32 percent)[1]
Complications
- Common complications of [disease name] include:
- [Complication 1]
- [Complication 2]
- [Complication 3]
Prognosis
- Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [--]%.
- Depending on the extent of the [tumor/disease progression] at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor/good/excellent.
- The presence of [characteristic of disease] is associated with a particularly [good/poor] prognosis among patients with [disease/malignancy].
- [Subtype of disease/malignancy] is associated with the most favorable prognosis.
- The prognosis varies with the [characteristic] of tumor; [subtype of disease/malignancy] have the most favorable prognosis.
References
- ↑ 1.0 1.1 1.2 1.3 Wall M, George D (February 1991). "Idiopathic intracranial hypertension. A prospective study of 50 patients". Brain. 114 ( Pt 1A): 155–80. PMID 1998880.
- ↑ 2.0 2.1 Wall M (December 1990). "The headache profile of idiopathic intracranial hypertension". Cephalalgia. 10 (6): 331–5. doi:10.1046/j.1468-2982.1990.1006331.x. PMID 2289234.
- ↑ 3.0 3.1 3.2 Giuseffi V, Wall M, Siegel PZ, Rojas PB (February 1991). "Symptoms and disease associations in idiopathic intracranial hypertension (pseudotumor cerebri): a case-control study". Neurology. 41 (2 ( Pt 1)): 239–44. PMID 1992368.
- ↑ Sismanis A, Butts FM, Hughes GB (January 1990). "Objective tinnitus in benign intracranial hypertension: an update". Laryngoscope. 100 (1): 33–6. doi:10.1288/00005537-199001000-00008. PMID 2293699.
- ↑ Lessell S (1992). "Pediatric pseudotumor cerebri (idiopathic intracranial hypertension)". Surv Ophthalmol. 37 (3): 155–66. PMID 1475750.
- ↑ Chari C, Rao NS (October 1991). "Benign intracranial hypertension--its unusual manifestations". Headache. 31 (9): 599–600. PMID 1774176.