Angiomyolipoma medical therapy
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Faizan Sheraz, M.D. [2]
Overview
Treatment options include selective renal artery embolization,nephron sparing surgery( enucleation or partial nephrectomy), complete and radical nephrectomy, radio-frequency ablation and everolimus. Angiomyolipomas found incidentally,asymptomatic, < 4 cm in size, generally requires no intervention beside periodic evaluation.Medium sized lesion(4-8 cm) should be closely followed with the serial imaging studies and elective intervention provided if the change in the size or symptoms noticed to increases the chances of renal function salvage..Larger lesion(>8cm), shown to progress to the development of the complication so treated elective.[1]
Treatment and management of the Angiomyolipoma depends largely on
- size of the tumors,
- signs and symptoms,
- presence or absence of Life threatening hemorrhage,
- its association with the tuberous sclerosis and the presence of the comorbities.[2]
Medical Therapy
Patients with loss of renal function should be monitored for:
- Hypertension
- Adverse effects of nephrotoxic drugs such as:
- NSAIDS
- IV contrast agents
References
- ↑ Dickinson M, Ruckle H, Beaghler M, Hadley HR (1998). "Renal angiomyolipoma: optimal treatment based on size and symptoms". Clin Nephrol. 49 (5): 281–6. PMID 9617489.
- ↑ Oesterling JE, Fishman EK, Goldman SM, Marshall FF (1986). "The management of renal angiomyolipoma". J Urol. 135 (6): 1121–4. PMID 3520013.