Hemolytic-uremic syndrome natural history, complications and prognosis

Hemolytic-uremic syndrome Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].

OR

Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].

OR

Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.

Natural History, Complications, and Prognosis

Natural History

• The symptoms of HUS usually develop after eating of contaminated food in the first diarrhea is watery and become to bloody later. and start with symptoms such as abdominal pain, nausea and vomiting accompany diarrhea , Fever is observed less commonly.
• The symptoms of HUS typically develop 5–15% of the cases.
• If left untreated 15% of patients with HUS may progress to develop rectal prolapse, acute renal failure , colonic gangrene , and mortality .

Complications

• Common complications of HUS include:
  • Approximately 15% of pations of EHEC‐associated gastroenteritis will develop HUS.
  • The most common cause of acute kidney injury (AKI) in childern .
  • Hypertension (HTN)
  • end-stage renal disease
  • 9% renal transplants in children and adolescents.
  • death

Prognosis

• Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [--]%.
• Depending on the extent of the [tumor/disease progression] at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor/good/excellent.
• The presence of [characteristic of disease] is associated with a particularly [good/poor] prognosis among patients with [disease/malignancy].
• [Subtype of disease/malignancy] is associated with the most favorable prognosis.
• The prognosis varies with the [characteristic] of tumor; [subtype of disease/malignancy] have the most favorable prognosis.