Hemolytic-uremic syndrome natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].

OR

Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].

OR

Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.

Natural History, Complications, and Prognosis

Natural History

• The symptoms of HUS usually develop after eating of contaminated food in the first diarrhea is watery and become to bloody later. and start with symptoms such as abdominal pain, nausea and vomiting accompany diarrhea , Fever is observed less commonly.
• The symptoms of HUS typically develop 5–15% of the cases.
• If left untreated 15% of patients with HUS may progress to develop rectal prolapse, acute renal failure , colonic gangrene , and mortality .

Complications

• Common complications of HUS include:
  • Approximately 15% of pations of EHEC‐associated gastroenteritis will develop HUS.
  • The most common cause of acute kidney injury (AKI) in childern .
  • Hypertension (HTN)
  • end-stage renal disease
  • 9% renal transplants in children and adolescents.
  • Neurological complications: hemiparesis, seizure, coma, stroke, coma, occur in approximately 10-50%.
  • death

Prognosis

Common complications of HUS include:

• Approximately 15% of pations of EHEC‐associated gastroenteritis will develop HUS.
• The most common cause of acute kidney injury (AKI) in childern .
• Hypertension (HTN)
• end-stage renal disease
• 9% renal transplants in children and adolescents.
• Neurological complications: hemiparesis, seizure, coma, stroke, coma, occur in approximately 10-50%.
• death