Thrombotic thrombocytopenic purpura classification
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Saeedeh Kowsarnia M.D.[2]
Overview
Classification
- Hereditary: congenital TTP, inherited TTP, familial TTP, Upshaw-Schulman syndrome (USS) is an autosomal recessive diseas
Insertions, deletions, missense, nonsense point mutations and splice site mutations of both alleles of ADAMS13 genes cause decrease in the amount and activity of the enzyme.
- Acquired: Existence of an inhibitory antibody against ADAMS13 due to the variety of conditions.