Thrombotic thrombocytopenic purpura diagnostic study of choice

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Complete blood count (CBC) with platelet count

Review of the peripheral blood smear

Serum electrolytes and creatinine

Serum lactate dehydrogenase (LDH)

Serum bilirubin level

Coagulation testing ( PT, aPTT, fibrinogen, D-dimer)

Serum haptoglobin level

Direct antiglobulin (Coombs) test (DAT)

ADAMTS13 activity and inhibitor testing

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