Multiple myeloma causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2] Shyam Patel [3]
Overview
The causes of multiple myeloma include sporadic mutations, such as TP53 mutation, and inherited predisposition.
Causes
Common causes
The causes of multiple myeloma include:
- Sporadic mutations and genetic predisposition.
- Mutations in tumor suppressors or oncogenes can cause multiple myeloma.
- Mutations in the tumor suppressor TP53 is most common.
- Chromosomal aberrations such as translocations can trigger the onset of malignancy and allow for uncontrolled plasma cell proliferation.[1]
Less common causes
Familial causes are less contributory to the development of multiple myeloma compared to sporadic causes.[1]
References
- ↑ 1.0 1.1 Rajkumar SV (2016). "Multiple myeloma: 2016 update on diagnosis, risk-stratification, and management". Am J Hematol. 91 (7): 719–34. doi:10.1002/ajh.24402. PMC 5291298. PMID 27291302.