Bleeding diathesis
Bleeding diathesis main page |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Mehrian Jafarizade, M.D [2]
Overview
Classification
Differential Diagnosis
Category | Sub-category | Diseases | History | Clinical manifestation | Laboratory testing | ||||||||
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Petechiae | Ecchymoses | Menorrhagia | Hematomas | Hemarthrosis | platelet count | Bleeding time (BT) | Prothrombin time (PT) | Platelet count activated partial thromboplastin time (aPTT) | Thrombin time (TT) | ||||
Platelet disorders | Thrombocytopenia | Infection-Induced Thrombocytopenia | |||||||||||
Medications-Induced Thrombocytopenia | |||||||||||||
Heparin-Induced Thrombocytopenia | |||||||||||||
Immune Thrombocytopenic Purpura (ITP) | |||||||||||||
Inherited Thrombocytopenia | |||||||||||||
Thrombotic Thrombocytopenic Purpura (TTP) | |||||||||||||
Hemolytic Uremic Syndrome | |||||||||||||
Thromobcytosis | Thrombocytosis in response to acute or chronic inflammation has not been associated with an increased thrombotic risk. In fact, patients with markedly elevated platelet counts (>1.5 million), usually seen in the setting of a myeloproliferative disorder, have an increased risk of bleeding. This appears to be due, at least in part, to acquired von Willebrand disease (VWD) due to platelet-VWF adhesion and removal. | ||||||||||||
Qualitative Disorders of Platelet Function | Inherited Disorders of Platelet Function | ||||||||||||
Acquired Disorders of Platelet Function | |||||||||||||
Von Willebrand Disease | |||||||||||||
Vessel wall disorders | Metabolic and Inflammatory Disorders | ||||||||||||
Inherited Disorders of the Vessel Wall | |||||||||||||
Coagulation disorders | Fibrinogen deficiency | ||||||||||||
Prothrombin deficiency | |||||||||||||
Factor V deficiency | |||||||||||||
Factor VII deficiency | |||||||||||||
Factor VIII deficiency | |||||||||||||
Factor IX deficiency | |||||||||||||
Factor X deficiency | |||||||||||||
Factor XI deficiency | |||||||||||||
Factor XII deficiency | |||||||||||||
HK deficiency | |||||||||||||
Prekallikrein deficiency | |||||||||||||
Factor XIII deficiency | |||||||||||||
Hemophilia | Type A deficiency | ||||||||||||
Type B deficiency | |||||||||||||
Type C deficiency | |||||||||||||
Rare diseases | Disseminated Intravascular Coagulation | ||||||||||||
Vitamin K Deficiency | |||||||||||||
Coagulation Disorders Associated with Liver Failure | |||||||||||||
Acquired Inhibitors of Coagulation Factors |