Spondyloarthropathy causes

causes

Albiet, all the progresses have been made through investigating the cause of spondyloarthropathies, the exact cause of this disease remained unclear, however, the role of genetic have been seen through numerous studies have been made in this field of study. Studies demonstrated the role of HLA-B27 in the occurrence of spondyloarthropathies.

Here are some locus, gene, and function of definite and probable genetic risk factors for SpA.

Overview of the locus, gene, and function of definite and probable genetic risk factors for SpA
locus	Gene	Function	Association with
			Ankylosing spondylitis	Psoriasis	Inflammatory bowel disease
6p21.3	HLA-B27	Antigene presentation	Yes	..	..
5q15	ERAP1	Aminopeptidase	Yes	Probable	..
1p31.2	IL23R	Cytokine receptor	Yes	Yes	Yes
2p15	..	..	Yes	..	..
21q22	..	..	Yes	..	..
12p13.2	TNFRSF1A	Cytokine receptor	Probable	..	Yes
16q22	TRADD	Signaling	Probable	..	..
9q32	TNFSF15	Inflammatory cytokine	Probable	..	Yes
2q14	IL1A	Inflammatory cytokine	Probable	..	..
2q12	IL1R2	Cytokine receptor	Probable	..	..
9q34	CARD9	Innate immune defence	Probable	..	..
4q21.1	ANTXR2	Vascular morphogenesis	Probable	..	..

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