Stevens-Johnson syndrome laboratory findings

Stevens-Johnson syndrome Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Stevens-Johnson Syndrome from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Study of Choice
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
X Ray
Echocardiography and Ultrasound
CT
MRI
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Stevens-Johnson syndrome laboratory findings On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Stevens-Johnson syndrome laboratory findings All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Stevens-Johnson syndrome laboratory findings
CDC on Stevens-Johnson syndrome laboratory findings
Stevens-Johnson syndrome laboratory findings in the news
Blogs on Stevens-Johnson syndrome laboratory findings
Directions to Hospitals Treating Stevens-Johnson syndrome
Risk calculators and risk factors for Stevens-Johnson syndrome laboratory findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

SJS is mainly diagnosed through the clinical skin findings. However skin biospy is helpful in making the definitive diagnosis. Other tests are done to either rule out the superimposed bacterial infection, measure disease severity or detect the causative agent or organism. Tests include CBC, BMP, Blood cultures, ESR, CRP, IL-6, ELISA for virus detection among others.

Laboratory Findings

Skin Biopsy is the only study that can make the definitive diagnosis of SJS. Other Lab tests are done to detect superimposed bacterial infection or in cases of severe or extensive skin involvement that is more commonly seen in TEN as compared to SJS.

First Step after suspicion of SJS is identifying and discontinuing the offending agent.

Following tests are done:

• Skin Biopsy: Lesional Biopsy and Perilesional Biopsy-To confirm the diagnosis of SJS and rule out other autoimmune skin conditions ( for example Pemphigus Vulgaris, Bullous pemphigoid, GVHD, SSSS, Linear IgA bullous dermatosis)
• Complete Blood Count: Abnormal blood counts can be seen in case of superimposed bacterial infections
• Metabolic Panel: Electrolyte disturbances, Glucose, BUN, Cr, Total protein, ALT, AST- Abnormalities seen in cases of extensive disease with Dehydration, Bacteremia, Hypovolumic shock and Multiorgan failure
• Bacterial and Fungal Cultures- Taken from Blood, Mucosal surfaces
• CRP, ESR, TNF-alpha, IL-6: Levels are typically elevated
• Bronchoscopy, EGD: may be needed to detect mucosal lesions
• HSV-IgM
• Mycoplasma IgM
• ELISA-to detect other causative viruses (HAV, HBV, HCV, HIV, EBV, Rubella,