Peripheral neuropathy laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]
Overview
Laboratory Findings
Laboratory findings consistent with the diagnosis of peripheral neuropathy according to the common causes of it, include:
- Tests for diagnosis the endocrine and metabolic Diseases which may cause peripheral neuropathy include:[1][2]
- Tests for diagnosis the Nutritional Diseases and vitamin deficiencies which may cause peripheral neuropathy include:[3][4][5]
- CBC; serum vitamin B12
- Plasma vitamin B6
- Plasma vitamin B6
- Blood vitamin B1
- Serum vitamin E
- Serum folate
- Tests for diagnosis the heavy Metal toxicities which may cause peripheral neuropathy include:[6]
- Lead
- Arsenic
- Mercury
- 24-hour urine heavy metals panel
- Tests for diagnosis the diseases which produce autoantibodies against peripheral nerves such as Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy and eaton lambert disease:[7][8]
- Calcium channel autoantibodies to rule out eaton lambert disease
- Anti acidic glycosphingolipids sialosyl paragloboside antibodies
- Anti sialosyl lactosaminyl paragloboside antibodies
- Anti sulfated glucuronyl paragloboside antibodies
- Rheumatologic, Autoimmune, and Vasculitic Disease:[9][10][11][12][13][14]
- ANA, dsDNA antibodies
- Cyclic citrullinated peptide antibody, rheumatoid factor
- Anti neutrophil cytoplasmic antibody
- Myeloperoxidase antibody
- Cryoglobulins
- Hepatitis B and C serology
- Parvovirus serology
- HIV-1 serology
- Proteinase 3 antibody
- Mitochondrial antibody
- SS-A/Ro antibody, SS-B/La antibody
- Thyroid peroxidase antibody
- Kappa/lambda light chains and free with ratio in serum
- Tests for diagnosis the other common causes of peripheral neuropathy include:
References
- ↑ Yu J (2014). "Endocrine disorders and the neurologic manifestations". Ann Pediatr Endocrinol Metab. 19 (4): 184–90. doi:10.6065/apem.2014.19.4.184. PMC 4316409. PMID 25654063.
- ↑ Callaghan B, Feldman E (2013). "The metabolic syndrome and neuropathy: therapeutic challenges and opportunities". Ann Neurol. 74 (3): 397–403. doi:10.1002/ana.23986. PMC 3881591. PMID 23929529.
- ↑ Hammond N, Wang Y, Dimachkie MM, Barohn RJ (2013). "Nutritional neuropathies". Neurol Clin. 31 (2): 477–89. doi:10.1016/j.ncl.2013.02.002. PMC 4199287. PMID 23642720.
- ↑ Kumar N (2007). "Nutritional neuropathies". Neurol Clin. 25 (1): 209–55. doi:10.1016/j.ncl.2006.11.001. PMID 17324726.
- ↑ Becker DA, Balcer LJ, Galetta SL (2012). "The Neurological Complications of Nutritional Deficiency following Bariatric Surgery". J Obes. 2012: 608534. doi:10.1155/2012/608534. PMC 3432875. PMID 22970351.
- ↑ Sharma B, Singh S, Siddiqi NJ (2014). "Biomedical implications of heavy metals induced imbalances in redox systems". Biomed Res Int. 2014: 640754. doi:10.1155/2014/640754. PMC 4145541. PMID 25184144.
- ↑ Yuki N, Tagawa Y, Handa S (1996). "Autoantibodies to peripheral nerve glycosphingolipids SPG, SLPG, and SGPG in Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy". J Neuroimmunol. 70 (1): 1–6. PMID 8862128.
- ↑ Leys K, Lang B, Johnston I, Newsom-Davis J (1991). "Calcium channel autoantibodies in the Lambert-Eaton myasthenic syndrome". Ann Neurol. 29 (3): 307–14. doi:10.1002/ana.410290313. PMID 1645944.
- ↑ Staff NP, Windebank AJ (2014). "Peripheral neuropathy due to vitamin deficiency, toxins, and medications". Continuum (Minneap Minn). 20 (5 Peripheral Nervous System Disorders): 1293–306. doi:10.1212/01.CON.0000455880.06675.5a. PMC 4208100. PMID 25299283.
- ↑ Bonaci-Nikolic B, Nikolic MM, Andrejevic S, Zoric S, Bukilica M (2005). "Antineutrophil cytoplasmic antibody (ANCA)-associated autoimmune diseases induced by antithyroid drugs: comparison with idiopathic ANCA vasculitides". Arthritis Res Ther. 7 (5): R1072–81. doi:10.1186/ar1789. PMC 1257438. PMID 16207324.
- ↑ Silva de Souza AW (2015). "Autoantibodies in systemic vasculitis". Front Immunol. 6: 184. doi:10.3389/fimmu.2015.00184. PMC 4406058. PMID 25954277.
- ↑ Nam TS, Lee SH, Park MS, Choi KH, Kim JT, Choi SM; et al. (2010). "Mononeuropathy multiplex in a patient with chronic active hepatitis B." J Clin Neurol. 6 (3): 156–8. doi:10.3988/jcn.2010.6.3.156. PMC 2950922. PMID 20944818.
- ↑ Wahren M, Tengnér P, Gunnarsson I, Lundberg I, Hedfors E, Ringertz NR; et al. (1998). "Ro/SS-A and La/SS-B antibody level variation in patients with Sjögren's syndrome and systemic lupus erythematosus". J Autoimmun. 11 (1): 29–38. doi:10.1006/jaut.1997.0173. PMID 9480721.
- ↑ Della-Torre E, Lanzillotta M, Doglioni C (2015). "Immunology of IgG4-related disease". Clin Exp Immunol. 181 (2): 191–206. doi:10.1111/cei.12641. PMC 4516435. PMID 25865251.
- ↑ Weis J, Brandner S, Lammens M, Sommer C, Vallat JM (2012). "Processing of nerve biopsies: a practical guide for neuropathologists". Clin Neuropathol. 31 (1): 7–23. PMC 3663462. PMID 22192700.
- ↑ Jain J, Singh R, Banait S, Verma N, Waghmare S (2014). "Magnitude of peripheral neuropathy in cirrhosis of liver patients from central rural India". Ann Indian Acad Neurol. 17 (4): 409–15. doi:10.4103/0972-2327.144012. PMC 4251014. PMID 25506162.
- ↑ Arnold R, Issar T, Krishnan AV, Pussell BA (2016). "Neurological complications in chronic kidney disease". JRSM Cardiovasc Dis. 5: 2048004016677687. doi:10.1177/2048004016677687. PMC 5102165. PMID 27867500.
- ↑ Ghosh S, Chaudhury PK, Goswami HK (2006). "An analysis of six cases of acute intermittent porphyria (AIP)". Indian J Psychiatry. 48 (3): 189–92. doi:10.4103/0019-5545.31584. PMC 2932991. PMID 20844651.
- ↑ Misra UK, Kalita J, Nair PP (2008). "Diagnostic approach to peripheral neuropathy". Ann Indian Acad Neurol. 11 (2): 89–97. doi:10.4103/0972-2327.41875. PMC 2771953. PMID 19893645.
- ↑ Argov Z, Mastaglia FL (1979). "Drug-induced peripheral neuropathies". Br Med J. 1 (6164): 663–6. PMC 1598252. PMID 219931.
- ↑ Rison RA, Beydoun SR (2016). "Paraproteinemic neuropathy: a practical review". BMC Neurol. 16: 13. doi:10.1186/s12883-016-0532-4. PMC 4731930. PMID 26821540.